Transcription of Toxicology Brief - ASPCApro
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Toxicology Brief - ASPCApro
580 JULY 2004 Veterinary MedicineToxicology Briefmanaging common poisonings in companion animalsIbuprofen toxicosis in dogs, cats, and ferretsEric Dunayer, MS, VMDA nonsteroidal anti-inflammatory drug (NSAID) de-rived from propionic acid, ibuprofen has analgesic,anti-inflammatory, and antipyretic effects. It is com-monly used in humans for short-term management of painand fever and for long-term control of arthritic pain. It comesin various strengths. For over-the-counter use, it is availablein 50- and 100-mg capsules or tablets (often chewable) and20- and 40-mg/ml liquids for children, and in 200-mg tabletsand capsules for adults. Prescription-strength tablets are 400,600, and 800 mg. Ibuprofen also can be found combinedwith other medications such as pseudoephedrine hydrochlo-ride or hydrocodone bitartrate. Common brand names ofibuprofen preparations include Advil (Wyeth), Midol (BayerHealthCare), and Motrin (McNeil Consumer), althoughibuprofen also is available in many generic humans, ibuprofen taken at standard dosages appearsto have a wide margin of safety.
582 JULY 2004 Veterinary Medicine circulation occurs.5 In dogs, the elimi- nation half-life is 3.9 to 5.3 hours.4 Ibuprofen has a narrow margin of safety in dogs. One recommended dosage is 5 mg/kg/day, divided.3 How- ever, signs of toxicosis have been seen
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