Transcutol® P

Transcutol PFor efficient drug solubilization and skin penetrationPeople make our nameABBREVIATIONSAPI: Active Pharmaceutical Ingredient; DEGEE: Diethylene glycol monoethyl ether; DMF: Drug Master File; DMSO: Dimethyl sulfoxide; FDA: US Food and Drug Administration; INCI: International Nomenclature of Cosmetic Ingredients; PG: Propylene glycol; Ph. Eur.: European Pharmacop ia; SC: Stratum corneum; UNII: Unique Ingredient Identifier; USP-NF: US Pharmacopoeia National Formulary; W/W: Weight / Weight3 Handling: measures to ensure product integrity Formulating with Transcutol P 610 Product description: a safe solvent 412 CS #1: Achieving the right balance between solubility and thermodynamic force14 CS #2: Transcutol P is suitable for a wide range of active ingredients 16 CS #3: Benefiting from synergy between Transcutol P and Lauroglycol FCC17 CS #4: Leveraging solvent evaporation for increased efficacyCase studies 117 A powerful solubilizer7 An efficient penetration and permeation enhancer9 Translating functionality into practical tipsProduct functionality 7 Regulatory information, precedence of use and safety 18 Technical support 21 Bibliography 22 Contents4 Transcutol P is a high purity grade of diethylene glycol monoethyl ether (DEGEE) (Figure 1) manufactured by the condensation of ethylene oxide and ethanol, followed by distillation.

the skin are dependent on API intrinsic properties (molecular weight, melting point, solubility, ….) and on the formulation (Figure 5). As such, the choice of excipients is critical. To illustrate the role of Transcutol® P and the importance of formulation, several case studies are described.

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