Transcription of True Identity by Immunohistochemistry - …
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True Identity by Immunohistochemistry - …
326 Arch Pathol Lab Med Vol 132, March 2008 Undifferentiated Tumor, Immunohistochemistry Bahrami et alUndifferentiated TumorTrue Identity by ImmunohistochemistryArmita Bahrami, MD; Luan D. Truong, MD; Jae Y. Ro, MD, PhD Context. Undifferentiated tumor refers to a hetero-geneous group of neoplasms with little or no evidence ofdifferentiation on routine light microscopic To identify the true Identity of undifferen-tiated tumors by immunohistochemical Sources. Review of the pertinent literature andthe authors For treatment and prognostic evaluation,it is crucial to delineate whether an undifferentiated neo-plasm is epithelial, mesenchymal, melanocytic, or hema-topoietic in nature. Application of a screening panel todemonstrate the expression of markers of major lineages isfundamental for determination of the broad category ofneoplasia. Because poorly differentiated carcinomas and inparticular sarcomatoid carcinomas are known to be het-erogeneous in their antigen expression, several epithelialmarkers in combination may be required to establish thecarcinomatous nature of tumor.
328 Arch Pathol Lab Med—Vol 132, March 2008 Undifferentiated Tumor, Immunohistochemistry—Bahrami et al Table 1. Malignant Neoplasms With Coexpression of Vimentin and Cytokeratin Carcinoma Renal cell carcinoma Endometrial adenocarcinoma Serous ovarian carcinoma
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