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Understanding Clinical Trial Design: A Tutorial for ...

Understanding Clinical Trial design : A Tutorial for Research Advocates Understanding Clinical Trial design : A Tutorial for Research Advocates Authored by Jane Perlmutter, PhD. for Research Advocacy Network's Advocate Institute Table of Contents List of Figures I. Introduction ..1 1 design of Clinical Trials: Striking a Balance .. 2. About the Tutorial ..1 2 Thinking About Clinical Trials .. 4. Trade-offs in Designing Clinical Trials ..2 3 Francis Bacon .. 11. II. Questions to Ask about Clinical Trials ..3 4 The Scientific Method .. 12. What Research Questions Are Being Addressed 5 Randomized Clinical Trials: The Gold Standard .. 14. In The Trial , And How Important Are They? ..4 6 Ronald Fisher .. 16. Why Should The Trial Be Conducted , Does The 7 Introduction of Randomized Controlled Trials .. 17. Scientific Rationale Adequately Support the Research 8 Statistical Inference in Hypothesis Testing .. 18. Questions? ..5 9 Errors in Hypothesis Testing.

addition to these trade-offs, trial designs must balance the priorities of many stakeholders, including trial sponsors, funders, regulators, principle investigators,

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