Transcription of Understanding DARZALEX Interference With Blood ...
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Understanding DARZALEX Interference With Blood ...
Understanding DARZALEX Interference With Blood Compatibility TestingDARZALEX (daratumumab) Results in a False Positive Indirect Coombs Test DARZALEX is a human monoclonal antibody for the treatment of multiple myeloma1 DARZALEX binds to CD38,2 a protein that is expressed on red Blood cells (RBCs)3-5 DARZALEX binding to RBCs interferes with Blood bank compatibility tests, including the antibody screening and crossmatching2 (both indirect Coombs tests) that are part of a routine pretransfusion workupRBCsPatient serumwithout antibodiesto minor antigenNo patient antibodiesto bind RBC antigensCoombsreagentNoagglutinationNega tiveindirectCoombs testRBCsPatient serumcontaining antibodiesto minor antigenPatient antibodiesbind RBC antigensCoombsreagentAgglutinationPositi veindirectCoombs testRBCsPatient serumcontaining DARZALEX DARZALEX binds CD38on RBCsCoombsreagentAgglutinationFalse positi
DARZALEX® (daratumumab) Results in a False Positive Indirect Coombs Test • DARZALEX® is a human monoclonal antibody for the treatment of multiple myeloma1 • ®DARZALEX binds to CD38,2 a protein that is expressed
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