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UNITED STATES PATENT AND TRADEMARK OFFICE …

Filed on behalf of: Junior Party, Broad Paper No. ____ By: Steven R. Trybus By: Raymond N. Nimrod Locke Lord LLP Zachariah Summers (pro hac) 111 South Wacker Drive Quinn Emanuel Urquhart & Sullivan, LLP Chicago, IL 60606 51 Madison Avenue Telephone: 312-443-0699 New York, NY 10010 Telephone: 212-849-7000 UNITED STATES PATENT AND TRADEMARK OFFICE before THE PATENT TRIAL AND APPEAL BOARD THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, and PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Patents 8,697,359; 8,771,945; 8,795,965; 8,865,406; 8,871,445; 8,889,356; 8,889,418; 8,895,308; 8,906,616; 8,932,814; 8,945,839; 8,993,233; 8,999,641; and 9,840,713; and Applications 14/704,551 and 15/330,876, Junior Party, v. SIGMA-ALDRICH CO., LLC, Application 15/456,204, Senior Party. PATENT Interference No. 106,133 (DK) (Technology Center 1600) BROAD OPPOSITION 1 i INTERFERENCE 106,133 BROAD OPPOSITION 1 TABLE OF CONTENTS I. PRECISE RELIEF REQUESTED.

UNITED STATES PATENT AND TRADEMARK OFFICE BEFORE THE PATENT TRIAL AND APPEAL BOARD THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF ... Ex. 2468, ¶¶ 277-282; MF14. In the early 2000s, well before 2012, ZFNs had been used for 16 site-specific, programmable gene editing to accomplish genome modifications in eukaryotic cells.

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