Transcription of Update on the Management of Refractory Coeliac Disease
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Update on the Management of Refractory Coeliac Disease
Management of Refractory Coeliac diseaseJ Gastrointestin Liver DisMarch 2007 No 1, 57-63 Address for correspondence:REVIEWSU pdate on the Management of Refractory Coeliac DiseaseAbdulbaqi Al-toma, Wieke HM Verbeek, Chris JJ MulderDepartment of Gastroenterology ,VU University Medical Center, Amsterdam, The NetherlandsProf. CJJ MulderUniversity Medical CenterDept. Box 70571005 MB Amsterdam, The NetherlandsE-mail: Refractory Coeliac Disease (RCD) is being currentlydefined as persisting or recurring villous atrophy with crypthyperplasia and increased intraepithelial lymphocytes inspite of a strict gluten free diet for more than 12 months orwhen severe persisting symptoms necessitate interventionindependent of the duration of the dietary therapy. Currentlytwo categories of RCD are being recognized: type I withoutaberrant T-cells and type II with aberrant T-cells detectedby immunophenotyping by flowcytometric analysis orimmunohistology of the intestinal mucosa.
Management of refractory coeliac disease J Gastrointestin Liver Dis March 2007 Vol.16 No 1, 57-63 Address for correspondence: REVIEWS Update on the Management of Refractory Coeliac Disease
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