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US/Italian Multicenter Collaboration

McCullough PA, Kelly RJ, Ruocco G, Lerma E, Tumlin J, Wheelan KR, Katz N, Lepor NE, Vijay K, Carter H, Singh B, McCullough SP, Bhambi BK, Palazzuoli A, De Ferrari GM, Milligan GP, Safder T, Tecson KM, Wang DD, McKinnon JE, O'Neill WW, Zervos M, Risch HA. Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection. Am J Med. 2020 Aug 7:S0002-9343(20)30673-2. doi: Epub ahead of print. PMID: 32771461; PMCID: Multicenter CollaborationAcademic Medical CentersPublic HeathIntegrated Health SystemsCommunity PracticeBiotech IndustrySpecialtiesInternal MedicineCritical CareNephrologyCardiologyElectrophysiolog yInfectious DiseasesOphthalmologyEpidemiologyBiostat isticsDay 0 Symptom Onset 7 days 14 days 21 days 30 days Untreated Mortality RiskCoughDifficulty BreathingFeverSore ThroatMalaiseBody AchesNasal StuffinessLoss of tasteAnorexiaNauseaDiarrheaChest Heaviness/PainDyspneaDesaturationSystemi c ThromboembolismOff-Target AntiviralsCorticosteroidsAntiplatelet Drugs/AntithromboticsSARS-Co

Malaise Body Aches Nasal Stuffiness Loss of taste Anorexia Nausea Diarrhea Chest Heaviness/Pain Dyspnea Desaturation Systemic Thromboembolism Off-Target Antivirals Corticosteroids Antiplatelet Drugs/Antithrombotics SARS-CoV-2 Nasal PCR+ Oral PCR/Ag+ ↑D-dimer ↑Hs-CRP ↓Lymphocytes

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