Transcription of Useful Pharmacokinetic Equations
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Equations /Useful_pharmacokinetic_equ_512 7 1 Useful Pharmacokinetic Equations Symbols D = dose = dosing interval CL = clearance Vd = volume of distribution ke = elimination rate constant ka = absorption rate constant F = fraction absorbed (bioavailability) K0 = infusion rate T = duration of infusion C = plasma concentration General Elimination rate constant kCLVdCCttCCtte lnlnln12211221 Half-life tVdCLkkee120 69320 693/.ln(). Intravenous bolus Initial concentration CDVd0 Plasma concentration (single dose) CCekte 0 Plasma concentration (multiple dose) CCeektkee 01 Peak (multiple dose) CCekemax 01 Trough (multiple dose) CCeekkeemin 01 Average concentration (steady state) CpDCLss Oral administration Plasma concentration (single dose) CFDkVd kkeeaaektktea Time of maximum concentration (single dose) tkkkkaeaemaxln Plasma concentration (multiple dose) CFDkVd kkeeeeaaektkktkeeaa 11 Time of maximum concentration (multiple dose) tkekekkakekaeeamaxln 11 Average concentration (steady state) CFDCL Clearance AUCFDoseCl deVkCl Equations /Useful_pharmacokinetic_equ_512 7 2 Constant rate infusion Plasma concentration (during infusion) CkCLekte 01 Plasma concentration (steady state) CkCL 0 Calculated clearance (Chiou equation) CLkCCVd CCCC t t 22012121221 Short-term infusion Peak (single dose) CDCL TekTemax( )11 Trough (single dose) CCekTemin( )
C:\Current Data\pha5127_Dose_Opt_I\equations\5127-28-equations.doc If the dosing involves a I.V. infusion (more equations): k T k t e t e e e e Vk T D C 1 (most general eq.) during infusion t = T so, k t e t e e Vk T D C 1 (during infusion) at steady …
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