Transcription of What Is Oxidative Stress? - 日本医師会
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What Is Oxidative Stress? - 日本医師会
JMAJ, July 2002 Vol. 45, No. 7271 what Is Oxidative Stress? JMAJ 45(7): 271 276, 2002 Toshikazu YOSHIKAWA* and Yuji NAITO**Professor* and Associate Professor**, First Department of Medicine,Kyoto Prefectural University of MedicineAbstract: Oxidative stress is well known to be involved in the pathogenesis oflifestyle-related diseases, including atherosclerosis, hypertension, diabetes mellitus,ischemic diseases, and malignancies. Oxidative stress has been defined as harm-ful because oxygen free radicals attack biological molecules such as lipids, pro-teins, and DNA. However, Oxidative stress also has a useful role in physiologicadaptation and in the regulation of intracellular signal transduction. Therefore, amore useful definition of Oxidative stress may be a state where Oxidative forcesexceed the antioxidant systems due to loss of the balance between them.
272 JMAJ, July 2002—Vol. 45, No. 7 Free Radicals, Active Oxygen Species, and Oxidative Stress Usually, an atom is composed of a central nucleus with pairs of electrons orbiting around
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