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When patients on warfarin need surgery

CLEVELAND CLINIC JOURNAL OF MEDICINE VOLUME 70 NUMBER 11 NOVEMBER 2003973HE MORE THAN2 million patients inNorth America who take warfarin1facea major problem should they need surgery oran invasive one hand, if they continue taking war-farin up to the time of surgery , they face anincreased risk of bleeding. Therefore, mostpatients need to stop taking warfarin about 5days before surgery the time it takes for itsantithrombotic effect to wear this time and afterward, however,they may be at increased risk of thromboem-bolism, as stopping warfarin may cause arebound hypercoagulable state (which hasbeen described but not validated in clinicalpractice).

such as tranexamic acid mouthwash to control local bleeding without stopping the warfarin. In a small study,13patients who underwent oral surgery used this mouthwash for 2 min-utes four times a day for 1 week afterward, and none of them developed postoperative bleed-ing or systemic side effects. Dermatologic procedures

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