B-Cell Development, Activation, and Differentiation
Nov 13, 2014 · VHDJH gene rearrangement, then B cell development stops and the cell undergoes apoptosis (1st checkpoint) • Pre-B cell receptor signaling causes transient decrease in RAG1/2 and loss of Tdt • Ensures that as soon as one heavy chain gene has been rearranged, no further recombination is possible (allelic exclusion)
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