造血干细胞发育的分子机制 - CAS
最近的研究表明, Hedgehog-Notch是生血内 皮的产生所必需的信号, 其后, 通过Scl 的诱导作用 产生造血干细胞[33]. 除此之外, Hedgehog 信号通路还 通过Crlra(calcitonin receptor-like receptor)调控Notch 信号通路, 进而调控动脉产生, 这一过程是VEGF 非 依赖性的[34].
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