Design of Phase II Clinical Trials - UC Davis Health
Drug is a vascular endothelial growth factor (VEGF) inhibitor 2 dose levels tested (2 mg/kg and 4 mg/kg), based on previous phase 1 & 2 studies Patients with advanced platinum-resistant ovarian cancer Simon minimax 2-stage design Primary outcome: objective response rate (ORR) Null hypothesis: ORR ≤ 5%
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