(unchanged in ESRF) Time to steady state: Approximately 72 hours. Metabolism: Extensive metabolism in the liver. Elimination: Primarily biliary excretion. Volume of distribution: 3.9L/kg 90% protein bound. Therefore increased risk of toxicity in hypoalbuminaemia. Volume of blood: Fill to line. Tube to use: Lavender top. Lab performing assay:
years and may lead to End Stage Renal Failure (ESRF); •CRF usually cause irreversible damage to the kidneys; •ARF is reversible and normal Renal Function can be
of oxycodone is impaired in ESRF (17). There is limited evidence for the use of oxycodone in RI. There is a single case report of a patient on chronic haemodialysis who received multiple doses of oxycodone as oxycodone/paracetamol tablets.
NOTE – Caution in elderly, CCF, ESRF adolescence, pregnancy (risk of cerebral and pulmonary oedema) When CBG<14.0mmol/L add 125ml/hour of 10% glucose to run alongside 0.9% Sodium Chloride (consider reducing rate of 0.9% sodium chloride to reduce risk of fluid overload) ACTION 4 Ensure treatment targets are being met TREATMENT 1. Fall in CBG ...