HYPOCELLULAR BONE MARROW… WHAT’S NEXT?

Laboratory Diagnosis of Hemoglobinopathies and Thalassemia

Diagnosis • Indications for Testing – Hemolytic anemia; family history of hemoglobinopathy • Laboratory Testing – Initial testing – CBC with peripheral smear – Polychromasia, spherocytes, schistocytes, sickle cells, Heinz bodies, basophilic stippling; however, the lack of any of these cells does not rule out hemolytic anemia

  Laboratory, Diagnosis, Laboratory diagnosis of

Method Validation and Verification - University of Utah

Feb 12, 2018 · • Precision, accuracy, reportable range and reference interval must be evaluated, at a minimum, for all nonwaived tests before patient use • No “one size fits all” approach to validation/verification 41

  Validation, Precision, Accuracy

Lymphoma Diagnostic Work-up from a Lab Perspective

Non-Hodgkin lymphoma (NHL) 2. Hodgkin (disease) lymphoma 3. Multiple myeloma Lymphomas are solid tumors of the hematopoietic system. Neoplasms of lymphoid origin, typically causing lymphadenopathy

  Neoplasm, Lymphoma, Hodgkin, Lymphoid, Hodgkin lymphoma

Resolution of ABO Discrepancies

4+0 A1 Cell B Cell 1+ Lectin Patient’s Cells D. biflorus 0 Antibody Screen I.S. (RT) AHG Check Cells Screening Cell 1 0 0 Screening Cell 2 0 0 Screening Cell 3 0 0 Auto Control 0 0 Forward Type Reverse Type Most Anti-A reagents react strongly with A2 Cells Unexpected Reactivity with A1 Cells No unexpected antibodies detected

  Creativity

Cytogenetics Lecture 1: Introduction to Clinical Cytogenetics

Cell Division and The Cell Cycle •Mitosis: division of somatic cells •Meiosis: division of gametic cells •Cell cycle: 4 phases: Mitosis (M), Gap1 (G1), Synthesis (S), Gap2 (G2) NCBI Bookshelf: Cooper, The Cell: A Molecular Approach, 2nd Ed 2000

  Cells, Somatic

Kidney Stones: Diagnosis, Treatment, & Future Prevention

Describe the clinical presentation, laboratory, and radiographic findings of an individual affected by a kidney stone. 2. Compare 3 composition types of kidney stones and their clinical management. 3. Differentiate spontaneous and familial risk factors for kidney stone development.

  Presentation

Microscopy of CSF & Body Fluids - University of Utah

Microscopy of CSF & Body Fluids May 13, 2019 Professor of Pathology University of Utah Health Executive Director, Clinical Trials & PharmaDx ARUP Laboratories

Diagnosis of Monoclonal Gammopathies

–Protein Electrophoresis • Serum • Urine –Immunofixation • Free light chain ratio assay Outline. Serum protein electrophoresis (sPEP) •Intended for the separation of human serum proteins •Divides proteins in five major fractions: albumin, alpha-1, alpha-2, beta and gamma .

  Protein, Serum, Electrophoresis, Serum protein electrophoresis, Protein electrophoresis

Hypersensitivity Reactions (Types I, II, III, IV)

pathogenesis of: • Autoimmune diseases – SLE (lupus nephritis), rheumatoid arthritis • Drug reactions – Allergies to penicillin and sulfonamides • Infectious diseases – Poststreptococcal glomerulonephritis, meningitis, hepatitis, mononucleosis, malaria, trypanosomiasis.

  Pathogenesis, Rheumatoid, Arthritis, Rheumatoid arthritis