Lecture 10: Multiple Testing
False Discovery Rate m 0 m-m 0 m V S R Called Significant U T m - R Not Called Significant True True Total Null Alternative V = # Type I errors [false positives] •False discovery rate (FDR) is designed to control the proportion of false positives among the set of rejected hypotheses (R)
Download Lecture 10: Multiple Testing
Information
Domain:
Source:
Link to this page:
Please notify us if you found a problem with this document:
Advertisement
Documents from same domain
Lecture 10: Multiple Testing - UW Genome Sciences
www.gs.washington.eduWhy Multiple Testing Matters Genomics = Lots of Data = Lots of Hypothesis Tests A typical microarray experiment might result in performing 10000 separate hypothesis tests.
Tests, Multiple, Testing, Hypothesis, Hypothesis tests, Multiple testing
DNA Isolation from Strawberries
www.gs.washington.edusource for extracting DNA because they are easy to pulverize and contain enzymes called pectinases and cellulases that help to break down cell walls. And most important, strawberries have eight copies of each chromosome (they are octoploid), so there is a lot of DNA to isolate. The purpose of each ingredient in the procedure is as follows:
Form, Isolation, Strawberries, Extracting, Dna isolation from strawberries
Lecture 7: Hypothesis Testing and ANOVA
www.gs.washington.edu•Calculate a test statistic in the sample data that is ... candidate gene. We then divide these N individuals into ... Sum of MS F Squares Source of df Variation! SST G k"1! SST E N"k! SST G k"1 SST E N"k. Non-Parametric Alternative • Kruskal-Wallis …
Lecture 4: Random Variables and Distributions
www.gs.washington.edu•Before data is collected, we regard observations as random variables (X 1,X 2,…,X n) •This implies that until data is collected, any function (statistic) of the observations (mean, sd, etc.) is also a random variable •Thus, any statistic, because it is a random variable, has a probability distribution - referred to as a sampling ...
I-9 Form: Instructions for Nonresident on H-1B or TN Visa
www.gs.washington.eduI-9 Form: Instructions for Nonresident on H-1B or TN visa Instructions for both New Hires and Updating & Reverification For more detailed information about completing Form I-9, employers and employees should refer to the Handbook for Employers: Instructions for Completing Form I-9 (M-274). _____
Lecture 5: Estimation - University of Washington
www.gs.washington.eduBayesian Estimation: ÒSimpleÓ Example ¥I want to estimate the recombination fraction between locus A and B from 5 heterozygous (AaBb) parents. I examine 30 gametes for each and observe 4, 3, 5, 6, and 7 recombinant gametes in the Þve parents. What is the mle of the recombination fraction? ¥Tedious to show Bayesian analysis. LetÕs simplify ...
Lecture 9: Linear Regression - University of Washington
www.gs.washington.eduLecture 9: Linear Regression. Goals • Linear regression in R •Estimating parameters and hypothesis testing ... •Previous coding would result in colinearity •Solution is to set up a series of dummy variable. In general for k levels you need k-1 dummy variables x 1 …
1. Plasmid structure 2. Plasmid replication and copy ...
www.gs.washington.eduPlasmid replication requires host DNA replication machinery. 2. Most wild plasmids carry genes needed for transfer and copy number ... Large or small region of homologous DNA cloned that will integrate into the chromosomal target. 5. Need a counter selection method to kill the donor cells 6. Screen for what you think is correct.
Lecture 2: Descriptive Statistics and Exploratory Data ...
www.gs.washington.eduMultivariate Data •Organize units into clusters •Descriptive, not inferential •Many approaches •“Clusters” always produced Clustering Data Reduction Approaches (PCA) •Reduce n-dimensional dataset into much smaller number •Finds a new (smaller) set of variables that retains most of the information in the total sample
Related documents
The True History of the Early Christian Church
www.herbert-armstrong.orgpreparation and the rise of a great FALSE CONSPIRACY will provide the key to unlock the understanding of all Church history over the past 1,900 years. You will be able to understand the teachings of true Christianity and the guidelines by which you can prove where God’s true Church has been throughout history and WHERE IT IS TODAY.
Writing Multiple Choice and True/False Exam Questions
uhhcopfacultyresource.weebly.comTrue/false questions (strictly speaking these are a sub-type of MCQ’s) Short answer and essay questions invite an open response from students. They are commonly used to assess critical thinking and logical reasoning by inviting students to analyze, synthesize and evaluate. They challenge students to create rather than select a response.
Definition of diagnostic accuracy. The two-by-two table ...
hbg.cochrane.orgTrue and false results DIAGNOSIS AND PROGNOSIS: CLINICAL AND RESEARCH PROBLEMS October 8-11, 2014 Gargnano Giovanni Casazza Università degli Studi di Milano The Cochrane Hepato-Biliary Group . The aim of a diagnostic accuracy study is to evaluate the association between the