Pharmaceutical Issues when Crushing, Opening or Splitting ...
insoluble crystals leads to a reduced rate of drug release e.g. Tegretol Retard, Adalat Retard. • Coating pellets – coating drug pellets with a slowly dissolving polymer of varying thickness can vary the drug release rate. The pellets can either be compressed into a tablet or put in gelatin capsules e.g. Slo-Phyllin, Inderal-LA.
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