DOPAMINE HYDROCHLORIDE INJ.KIT600 - …

1 2015 5 2 2011 8 872119 IF 2008 200 DOPAMINE HYDROCHLORIDE 600 DOPAMINE HYDROCHLORIDE 200 1 (200mL) 200mg 600 1 (200mL) 600mg JAN DOPAMINE HYDROCHLORIDE JAN DOPAMINE HYDROCHLORIDE INN 200 600 1992 2 26 2004 7 9 2004 7 30 1992 2 29 2004 7 9 2004 7 30 0120-189-522 TEL 03-5229-3906 FAX 03-5229-3955 9:00 17:40 2015 4 # # IF 1.

2 63 2 IF IF 10 9 3 IF 10 20 9 IF 2. IF IF IF IF IF A4 9 IF IF 2 IF IF IF IF IF 2008 IF 2008 IF PDF IF IF 2008 21 4 IF 2008

3 IF 3. IF IF 2008 MR PDF IT MR IF IF IF MR IF IF IF 4. IF IF IF 2008 9 E I 1 1 1 II 2 2 2 2 2 ( )

4 2 2 2 III 3 3 3 3 3 IV 4 4 4 4 4 4 5 ( ) 5 6 6 10 6 11 6 12 6 13 6 14 6 V 7 7 7 8 VI 9 9 9 VII 10 10 10 10 10 10 11 11 VIII ( ) 12 12 ( )

5 12 12 12 12 12 12 13 13 10 13 11 13 12 13 13 13 14 14 15 14 16 14 IX 15 15 15 X 16 16 16 16 16 16 16 16 17 17 10 17 11 17 12 17 13 17 14 17 15 17 16 17 17 17 XI 18 18 18 XII 18 18 18 XIII 19 19 _ I 1.

6 2. 200 600 4 2 16 7 2015 4 1 (1) 200 600 5% (2) (3) (4) - 1 - II 1. (1) (2) (3) 2. (1) (2) (3) 3. 4. 5. 6. 7. CAS 200 600 DOPAMINE HYDROCHLORIDE 200 DOPAMINE HYDROCHLORIDE 600 JAN DOPAMINE HYDROCHLORIDE JAN DOPAMINE HYDROCHLORIDE INN -opamine C8H11NO2 HCl 4-(2-Aminoethyl)benzene-1,2-diol monohydrochloride (IUPAC) DOA 62-31-7 DOPAMINE HYDROCHLORIDE 51-61-6 DOPAMINE - 2 - III 1.

7 (1) (2) 1) 2) pH (3) (4) (5) (6) (7) 2. 3. 4. (95) 2 248 C pKa1= pKa2= 2 280nm 249nm 280nm 249nm A AE E 280nm 138 145 pH ~ 50mL (1) ( 280nm) (2) (3) (1) - 3 - IV 1 (1) (2) pH pH (3) 2 (1) (2) (3) (4) (5) 3 4 5 200 600 200mg 600mg 10g 60mg pH pH ( ) ~ IV-1.

8 IV-1. 200 1 200mL Na Cl 600 1 200mL Na Cl 1. 2. VIII 14 3 200 600 3 3 - 4 - 6 7 1. 40 C 75% 6 4 (1) 200 2 4 6 pH 97 103 102 103 102 103 (2) 600 2 4 6 pH 97 103 102 103 102 103 2. 36 3 (1) 200 36 pH 97 103 (2) 600 36 pH 97 103 1.

9 2. pH 1 1 10mL 10mL 1 1 10mL pH pH pH 10mL pH pH - 5 - 8 9 10 11 12 13 14 (1) 200 pH 1 2 3 4 5 6 7 8 9 10 11 12 13 14 10mL (2) 600 pH 1 2 3 4 5 6 7 8 9 10 11 12 13 14 10mL (1) 280nm (1) 280nm 3,4- (3,4-DMPA) X. 4 - 6 - V 1 2 (1) (2) (3) 1 1 5 g/kg 20 g/kg mL - 7 - 3 (1) (2) (3) (4) (5) 1) 2) 3) 4) (6) 1) 2) - 8 - VI 1 2 (1) (2) (3)

10 D1 cAMP Na+ D 1 1 - 9 - VII 1 (1) (2) (3) (4) (5) (6) 2 (1) (2) (3) (4) (5) (6) (7) 3 4 (1) (2) (3) (4) (5) 5 (1) (2) CYP450 2 2 2 MAO COMT 2 1 - 10 - (3) (4) (5) 6 (1) (2) (3) 7 2 2 6 14C- Ci/872 g/1,000mL 4 40 53 9 5 97 75 25 2 - 11 - VIII 1 2 3 4 5 6 7 (1) (2)