Transcription of Department of Medical Oncology Chemotherapy …
1 Department of Medical Oncology Chemotherapy Protocols 3rd Edition 113 Mesna Dose Guidelines (RKG/OF/MK December 05) IV Ifosfamide administered over 4 hours, day 1 only, single dose 20% of total ifosfamide dose @ t-15min prior to bolus, given as a bolus 20% of total ifosfamide dose given as a bolus @ 4hours and @ 8 hours post ifosfamide treatment. or preferably Oral Mesna post-ifosfamide infusion (see below) Ifosfamide Infusion >4 hours, R-ICE Equivalent of 20% total Ifosfamide dose given as IV bolus pre-ifosfamide ifusion Equivalence of 100% total Ifosfamide dose given as IV infusion over 24 hours (concurrently with Ifosfamide) Equivalence of 60% total Ifosfamide dose given as IV infusion over 12 hours Total Mesna dose = 180% of total Ifosfamide dose Ifosfamide given as a long term infusion, CIV over 24 hours for 3 days or Given over 4 hours for more than 1 day.
2 Equivalence of 20% total Ifosfamide dose IV bolus pre Ifosfamide infusion Equivalence of 100% total Ifosfamide dose IV concurrent with Ifosfamide Equivalence of 60% total Ifosfamide dose over 12 hours after final 24 hour infusion Total Mesna dose = 180% of total Ifosfamide dose Alternatively Oral Mesna post-ifosfamide infusion 40% oral when Ifosfamide infusion has stopped 40% after 2 hours 40% after 6 hours Total mesna dose = 120% po (= 60% IV)
