Transcription of NUDT15 遺伝子多型検査の保険適用と ... - jspho.jp
1 NUDT15 .. NUDT15 2019. 2 1 . 2100 . 1 . NUDT15 . 1) .. >T >A . >T >A .. NUDT15 . NUDT15 Cys/Cys 2% 6 . 6-MP 6MP . 5-10mg/m2 2) . 10mg/m2 45-55mg/m2 .. Cys/Arg . 50-60mg/m2 . 2) .. NUDT15 .. 1) Moriyama T, Nishii R, Perez-Andreu V et al. NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity. Nat Genet 48(4): 367-73, 2016. 2) Relling MV, Schwab M, Whirl-Carrillo M et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for thiopurine dosing based on TPMT and NUDT15 genotypes: 2018 update. Clin Pharmacol Ther. 2018 Nov 17. [Epub ahead of print]. 2019.
