Comprehensive Placental Tissue Matrix & Amniotic

1 Comprehensive Placental TissueMatrix & AmnioticSolutions Advantages of Amniotic & Placental TissueMODULATE CORRECT Tissue RECONSTRUCTIONThe Placental Extracellular Matrix (ECM) modulates correct Tissue reconstruction rather than scar Tissue formation. This ECM includes growth factors, fibronectin, laminin, hyaluronic acid, proteoglycans, and other *REGULATES INFLAMMATION & FIBROSISAnti-inflammatory and anti-fibrotic proteins in Placental ECMs reduce inflammation, fibrous Tissue growth, and potential scar Tissue formation as they downregulate TGF-B, suppress pro-inflammatory cytokines, and inhibit MMPs and fibroblast , 3*NON-IMMUNOGENICP lacental tissues possess little risk of foreign body reaction in the patient, which can lead to fibrosis and graft failure. They perform a similar role during pregnancy, preventing a response between baby and , 5*ANTI-MICROBIALP lacental Tissue contains components that help to create a healthy environment by potentially reducing bacteria counts in the wound.

2 Its antibacterial effects have been demonstrated against a wide range of bacteria. *FOUNDATION FOR REGENERATIONP lacental ECMs contain Collagens I, III, IV, V, VI, VII, and fibrous proteins that provide a structural scaffold to support migration. Fibronectin, integrins, laminin, and hyaluronan also play a key role in proliferation, differentiation and adherence to the , 5* Data on file at Human Regenerative Technologies, Liu J, et al. Update on Amniotic membrane transplantation. Expert Rev Ophthalmol., 2010;5(5), Dua HS, et al. The Amniotic membrane in ophthalmology. Survey of Ophthalmology, 2004;49(1) Hao Y, et al. Identification of antiangiogenic and anti-inflammatory proteins in human Amniotic membrane. Cornea. 2000;19 Kubo M, et al. Immunogenicity of human Amniotic membrane in experimental xenotransplantation. Invest Ophthalmol Vis Sci, 2001;42(7) Hori J, et al. Immunological characteristics of Amniotic epithelium. Cornea, 2006;25:S53-S58.

3 *Statements are based on studies of amnion and/or Placental tissues generally and are not specific to VIAFLOW or ACTISHIELD .ACTISHIELD & ACTISHIELD CF Amniotic Barrier MembranesPRODUCT DESCRIPTION ACTISHIELD and ACTISHIELD CF Amniotic Barrier Membranes are biologic allografts derived from dehydrated human Amniotic Tissue . ACTISHIELD and ACTISHIELD CF membranes are sterilized post packaging. Two thicknesses available > Amnion only (ACTISHIELD CF) > Chorion based membrane (ACTISHIELD ) Ideal handling, both dry and wet* Adheres well without sutures* Easy to apply topically and internally* Creates no additional bulk at the site* 5 year shelf life at ambient temperatureVIAFLOW & VIAFLOW C Flowable Placental Tissue MatricesPRODUCT DESCRIPTIONVIAFLOW & VIAFLOW C Flowable Placental Tissue Matrices are unique, pre-mixed, Tissue Matrix allografts, processed from human Placental tissues. This Tissue Matrix contains collagens, growth factors, and other key biologic components.

4 * Two configurations available > Ambient temperature (VIAFLOW ) > Cryopreserved (VIAFLOW C) 5 year shelf life at ambient temperature (VIAFLOW ) 5 year shelf life at -40o C (VIAFLOW C) Flowable through a 23G needle Injectable to target defects quickly and precisely Easily mixable with autologous fluids**Data on file at Human Regenerative Technologies, InformationPart#DescriptionAM20-2X04 ACTISHIELD Amniotic Barrier Membrane 2x4cm AM20-4X04 ACTISHIELD Amniotic Barrier Membrane 4x4cmAM20-4X08 ACTISHIELD Amniotic Barrier Membrane 4x8cmACTISHIELD Amniotic Barrier MembranePart#DescriptionAMAF-0005 VIAFLOW Flowable Placental Tissue Matrix Flowable Placental Tissue Matrix Flowable Placental Tissue Matrix Flowable Placental Tissue MatrixPart#DescriptionAMCF-0010 VIAFLOW C Cryopreserved Flowable Placental Tissue Matrix C Cryopreserved Flowable Placental Tissue MatrixPart#DescriptionAM45-2X04 ACTISHIELD CF Amniotic Barrier Membrane 2x4cm AM45-4X04 ACTISHIELD CF Amniotic Barrier Membrane 4x4cmAM45-4X08 ACTISHIELD CF Amniotic Barrier Membrane 4x8cmACTISHIELD CF Amniotic Barrier Membrane and denote Trademarks and Registered Trademarks of Wright Medical Group or its affiliates.

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