Cellular control of cholesterol - Yale University

Major Class of Serum Lipoproteins Composition (wt%) Lipoprotein Density (g/ml) Protein Phospholipids Free Cholesterol Cholesteryl esters Triacylclyerols Chylomicrons <1.006 2 9 1 3 85 VLDL 0.95-1.006 10 18 7 12 50 LDL 1.006-1.063 23 20 8 37 10 HDL 1.063-1.210 55 24 2 15 4

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  Serum, Cholesterol

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Blood vessels: the endothelium - Yale University

medcell.med.yale.edu

Endothelial cells regulate passage of immune cells into surrounding tissue. Not only must specific proteins exit the blood but immune cells must also cross the endothelium to enter the surrounding tissue to fight infections. Given the significantly larger size of cells compared to proteins, this would seem to be a near impossible challenge.

  Blood, Cells, Endothelial, Endothelial cells

Connective Tissue - Yale University

medcell.med.yale.edu

Collagen is the most abundant class of proteins and pound for pound some are as strong as steel. There are several di!erent types of collagens and their locations within the body varies. Most collagens, about 80-90% of total collagen, form fibers that provide the most mechanical strength. ... Fibers -> aggregation of fibrils.

  Tissue, Brief, Steel, Connective, Connective tissue

Cell Communication - Yale University

medcell.med.yale.edu

structure. Estrogen receptor Progesterone receptor Glucocorticoid receptor Thyroxine receptor Retinoic acid receptor General structure Variable DNA binding Ligand-binding Steroid receptors share common motifs; DNA-binding domain, steroid-binding domain and a variable domain that functions as activator of transcription.

  Communication, Structure, Cells, Cell communication

Epithelial Structure - Yale University

medcell.med.yale.edu

transport glucose from lumen of intestine to into blood stream. Na symport channels help the cells move glucose against a concentration gradient from the lumen of the intestine into the cell. The basal surface of the cells contains passive glucose channels that allow glucose to leave the cell and enter capillaries beneath the basement membrane.

  Blood, Epithelial, Glucose

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NEONATAL PHARMACOLOGY - University of Florida

neonatology.pediatrics.med.ufl.edu

• Human placenta unique from other species as organ of drug transfer ... • Increased free fraction of highly bound drugs • Result: increased exposure across placenta to protein-bound drugs. ... • Free fatty acids and unconjugated bilirubin displace drugs from protein binding sites – Ampicillin, sulfonamides, phenytoin, diazepam ...

  Human, Bound, Neonatal, Acid, Fatty, Pharmacology, Fatty acids, Neonatal pharmacology

PROTEIN BINDING OF DRUGS - Jiwaji University

www.jiwaji.edu

Binding of drug to human serum Albumin. • It is the most abundant plasma protein (59%), having M.W. of 65,000 with large drug binding capacity. • Both endogenous compounds such as fatty acid, bilirubin as well as drug binds to HSA. • Four diff. sites on HSA for drug binding. Site I: warfarin & azapropazone binding site.

  Human, Fatty, Serum, To human serum

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