Rodent Carcinogenesis Bioassay

S2 (R1) Step 5 Genotoxicity testing and data ...

sensitivity for detection of rodent carcinogens and broadens the spectrum of genetic events detected, but also decreases the specificity of prediction; i.e., increases the incidence of positive results that do not correlate with rodent carcinogenicity . Nevertheless, a battery approach is still reasonable because

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