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TRAMADOL Pre-Review Report - WHO
www.who.int39th ECDD (2017) Agenda item 5.3 Tramadol Page 6 of 36 Summary Tramadol is a centrally acting analgesic with a multimode of action. It acts on serotonergic and noradrenergic nociception, while its metabolite O-desmethyltramadol acts as a mu agonist on the