参考1－1 有害性総合評価表 物質名：エピクロロヒドリン

1 28 28 GHS LC50 3000 ppm(2h) 500 ppm(4h) 624 ppm(4h) 354 ppm(6h) 360 ppm(6h) 250 ppm(8h) ( ) 780 ppm(2h) 561 ppm(4h) 445 ppm(4h) 4 354 ppm LD50 40-260mg/kg 195-238 mg/kg 178-280mg/kg 345 mg/kg LD50 250mg/kg 300-1038 mg/kg 5% 20% 10%

2 2 8-11 A 29 29 GHS in vivo somatic cell mutation tests ( SCE ) in vitro mutagenicity tests( (SCE) DNA ) IARC 2A in vitro in vivo RL(10-4) = 80 g/ 3 RL(10-3) = 800 g/ 3 UR 10-6( g/m3)-1 EPA IRIS (RL(10-4)) (UR) IRIS 20m3/ 365 / 10m3/ 240 / / 45/75 RL(10-4) RL(10-4)/(10/20 240/365 45/75) 80 g/m3 10-1 ppm ppm RL(10-3) RL(10-3)/(10/20 240/365 45/75) 800 g/m3 ppm LOAEL = 5 ppm 0 5 25 50 ppm 6 / 5 / 10 25 50 ppm 50 ppm UF 10 LOAEL mg/m3 6/8 5/5 10 = mg/m3 ppm LOAEL 20 ppm ppm( mg/m3) 18 LOAEL 20 ppm(76 / 3)

3 30 30 GHS 40 ppm 151 mg/m3 2 LOAEL 20 ppm NOAEL 10 LOAEL 2 .0ppm NOAEL ppm ( mg/m3) NOAEL 6 / 5 / 13 50 ppm 25 ppm 5 ppm US EPA 5ppm NOAEL RfC mg/m3 ppm 98 24 mg/m3 ( ) NOAEL Sprague-Dawley 10 1 0 1 5 25 mg/kg/day 90 25 mg/kg/day 5 mg/kg/day GDWQ 1996 2 5 / 2 mg/kg/day 2 mg/kg/day LOAEL TDI NOAEL UF 10 (GHS )13 NOAEL 1 24 /8 7 /5 UF (10) NOAEL (1) (1) mg/m3 24/8 7 /5 100 mg/m3 10-1ppm NOAEL 5 ppm ( mg/m3)

4 5 NOAEL 6 / 5 / 13 50 ppm 25 ppm 5 ppm 31 31 GHS US EPA 5ppm NOAEL RfC mg/m3 ppm 98 24 mg/m3 ( ) NOAEL Sprague-Dawley 10 1 0 1 5 25 mg/kg/day 90 25 mg/kg/day 5 mg/kg/day GDWQ 1996 2 5 / 2 mg/kg/day 2 mg/kg/day LOAEL TDI NOAEL UF 10 13 NOAEL 1 6 /8 5 /5 UF (10) NOAEL (1) (1) mg/m3 6/8 5 /5 10 mg/m3 10-1ppm ACGIH(2004 ) TLV-TWA TLV-TWA LC50 mg/L 96-h)

5 EC50 24 mg/L (48-h) BOD 3- -1, 2- BCF log o/w 3- -1, 2- Raphidocellis subcapitataus 16-17mg/L 96h ppm RL(10-4) ppm ACGIH TLV TWA 32 32 GHS LC50 143-150 ppm(2h) 75-80 ppm(2h) 2 4 101-106 ppm 53-57 ppm LD50 625-1,660 mg/kg 780-1,620 mg/kg LD50 ( ) ( ) 380 ppm 30 / in vitro mutagenicity tests in vivo mutagenicity test in vivo NOEL NOAEL LOAEL IARC:2A ACGIH:A3 2 B in vitro TA1535,TA100 WP2hcr SCE DNA Hela DNA UDS UR 10-5 ( g/m3)-1 RL(10-4): g/m3 ( ) RL(10-3): 53 g/m3 ( ) 33 33.

6 Unit risk= 10-5 ( g/m3)-1 (IRIS Oral slope factor ) Oral slope factor (IRIS)= (mg/kg-day)-1 IRIS 20m3/ 365 / RL(10-4) RL(10-4)/(10/20 240/365 45/75) g/m3 5 10- ppm ppm RL(10-3) RL(10-3)/(10/20 240/365 45/75) 53 g/m3 5 10- ppm ppm NOAEL=15mg/kg 50,100mg/kg 3 / 104 100mg/kg 15,30mg/kg 3 / 104 30mg/kg C UF 100 15 mg/kg 60 kg / 10 m3 3 /5 100 = ppm NOAEL 50 mg/kg/day 50, 100 mg/kg/day 6-15 100 mg/kg/day UF 10 5 mg/kg/day x 60 kg/10 m3 x 1/10 = 3 mg/m3 ( ppm)

7 LOAEL 5 2ppm 1 LD50 NOAEL 34 34 LOAEL ppm ppm Takata-Ara Weltmann UF 10 LOAEL UF LOAEL NOAEL (10) ppm 10 ppm NOAEL 25 mg/kg 25 50 100 mg/kg 3 / 26 50 mg/kg 100 mg/kg # # hyperplasia of the liver HSDB UF 10 13 NOAEL UF (10) NOAEL (1) (1) 60kg 10m3 3 /5 25 mg/kg/day 60/10 3 /5 10 9 mg/m3 ( ppm) ACGIH TWA 1ppm ACGIH Documentation (2001) 1ppm( )

8 TLV TWA Skin SEN TLV-STEL LC50 mg/L(96-h) EC50 mg/L(48-h) ErC50 EC50 NOEC >1 35 35 NOEC 1 BCF % BOD 2 log o/w GHS LC50(96 h): mg/L pH 7 9 10 LogPow ppm RL(10-4) ppm ACGIH TLV-TWA 36 36 1,3- GHS LC50 129000 ppm(4h) 121000 122170 ppm(2h) LD50 5480-5500 mg/kg 3200-3210 mg/kg 2,000 ppm 7 4,000 ppm 6 in vivo heritable germ cell mutagenicity test in vivo somatic cell mutagenicity tests ( )

9 In vitro mutagenicity tests L5178Y CHO 37 37 GHS IARC 2A In vitro In vivo B6C3F1 RL(10-4) = 3 g/m3 RL(10-3) = 30 g/m3 UR 3 10-5( g/m3)-1 EPA IRIS (RL(10-4)) (UR) 10m3/ 240 / / 45/75 RL(10-4) RL(10-4)/(10/20 240/365 45/75) 3 g/m3 7 10- ppm ppm RL(10-3) RL(10-3)/(10/20 240/365 45/75) 30 g/m3 7 10- ppm ppm NOAEL < 40 ppm 6-15 10 6 / 40 200 1,000 ppm 200 ppm 40 ppm 200 ppm 1,000 ppm UF 100 mg/m3 6/8 1/100 = mg/ 3 38 38 GHS 1, 3- ppm NOEL NOAEL LOAEL UR ,000 ppm NOAEL LOAEL ppm ( mg/m3)

10 1ppm= mg/m3 0, , 20, , 200 , 625 ppm 6 / , 5 / 2 NTP ppm EU UF 100 (GHS )13 LOAEL 10 1 UF (10) LOAEL (10) (1) 6 /8 5 /5 mg/m3 6/8 5 /5 100 mg/m3 ppm TLV-TWA 2 ppm ACGIH(2004) 1,3- TLV-TWA 2 ppm mg/m3 TLV LC50 mg/L (24-h) EC50 ( mg/L 48hEC50 QSAR ) EU-RAR ErC50 ( mg/L 72hErC50 QSAR ) EU-RAR BCF log o/w