注1、2） - jsts.gr.jp

1 TIA. 1 . 1-1.. 1 rt-PA . 3 . A .. rt-PA . 1 2 .. 2 t-PA desmoteplase . C2 . 3 . 60,000 / . 5 .. C1 . 1 rt-PA. 1 . 1 3 . 2 . 3 TIA 3 . 21 14 .. 185. mmHg 110mmHg 3.. 50mg/dL 400mg/dL 10 /mm . PT-INR APTT .. CT CT/MRI . 3 75 NIHSS 23 JCS100 . 10 3 .. 4 . a 24 . b . 48.. c /kg 10 . 1 2 1 . d . SCU 36 . 180mmHg 105mmHg . 24 .. CT MRI .. e . 1 . 15 . 1 7 30 . 7 24 1 . f . 2 15 . 2 8 30 . 8 24 1 . 180mmHg 105mmHg .. g .. 2 rt-PA 1 . 1 CT MRI 24 . 2 . SCU .. 3 . 4 .. 3 rt-PA . 2009 49. 1 . 2 . 3 b 1 . 3 5 . 6 . 3-6 . b The Cochrane stroke group 3.

2 Rt-PA 3 6 . 7 . 3 a . 8-10 .. 11 . a . rt-PA . 12 . 2008 9 3 rt- 13 . PA ECASS b . 2002 2003 3 . J-ACT . 14 . 2005 10 . J-ACT .. 60,000 / 7 5 . 15 . b .. 16-19 .. a .. rt-PA .. 1 rt-PA rt-PA. 2005 10 2005 27 327-354. 2 The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995 333 . 1581-1587. 3 Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R, et al. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke.

3 The European Cooperative Acute Stroke Study ECASS .JAMA 1995 274 1017-1025. 4 Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, et al. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke ECASS II . Second European-Australasian Acute Stroke Study Investigators. Lancet 1998 352 1245-1251. 5 Clark WM, Albers GW, for the ATLANTIS Stroke Study Investigators. The ATLANTIS. rt-PA Alteplase Acute Stroke Trial nal results. Stroke 1999 30 234.

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5 Intravenous tissue-type plasminogen activator for treatment of acute stroke the Standard Treatment with Alteplase to Reverse Stroke STARS study. JAMA 2000 283 1145-1150. 9 Hill MD, Buchan AM. Thrombolysis for acute ischemic stroke results of the Canadian Alteplase for Stroke Effectiveness Study. CMAJ 2005 172 1307-1312. 10 Wahlgren N, Ahmed N, Davalos A, Ford GA, Grond M, Hacke W, et al. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke- Monitoring Study SITS-MOST an observational study.

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7 N Engl J Med 2008 359 . 1317-1329. 14 Yamaguchi T, Mori E, Minematsu K, Nakagawara J, Hashi K, Saito I, et al. Alteplase at mg/kg for acute ischemic stroke within 3 hours of onset Japan Alteplase Clinical Trial J-ACT . Stroke 2006 37 1810-1815. 15 . -Placebo - 1985 13 711-751. 16 Multicentre Acute Stroke Trial--Italy MAST-I Group. Randomised controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischaemic stroke. Lancet 1995 346 1509-1514. 17 Hommel M, Boissel JP, Cornu C, Boutitie F, Lees KR, Besson G, et al.

8 Termination of trial of streptokinase in severe acute ischaemic stroke. MAST Study Group. Lancet 1995 345 . 57. 18 Donnan GA, Davis SM, Chambers BR, Gates PC, Hankey GJ, McNeil JJ, et al. Streptokinase for acute ischemic stroke with relationship to time of administration Australian Streptokinase ASK Trial Study Group. JAMA 1996 276 961-966. 19 The Multicenter Acute Stroke Trial--Europe Study Group. Thrombolytic therapy with streptokinase in acute ischemic stroke. N Engl J Med 1996 335 145-150. 2009 51.