案1 抗微生物薬適正使用の手引き 第一版

1 1.. 1 (1) .. 1 (2) .. 2 (3) .. 2 (4) .. 2 (5) .. 2 2.. 4 (1) .. 4 (2) .. 4 (3) .. 4 (4) .. 5 3.. 7 (1) .. 7 (2) .. 7 (3) .. 8 (4) .. 12 (5) .. 17 4.. 21 (1) .. 21 (2) .. 21 (3) .. 21 (4) .. 24 (5) .. 27 5.. 30 (1).

2 30 (2) .. 34 (3) .. 35 6.. 37 1 1. (1) 1 1 1 1 2050 1,000 2,3 1980 1 4 (Antimicrobial Resistance.)

3 AMR) 2015 5 2016 4 (AMR) 1 1 1 DDD(Defined Daily Dose) 2 5 3 1,5 30% 6 1 (AMR) antimicrobial agents, antimicrobials ( )

4 ( ) (antibacterial agents) (antibiotics) ( ) 2 DDD: Defined Daily Dose DDD 2 (2) AMR 2020 2013 3 2 1 (3) ( )

5 (4) 5,6 (5) (Japanese Association for Infectious Diseases.)

6 JAID) (Japanese Society of Chemotherapy: JSC) 3 (Centers for Disease Control and Prevention: CDC) (American College of Physician: ACP) (Infectious Diseases Society of America: IDSA) (American Academy of Pediatrics: AAP) (European Society of Clinical Microbiology and Infectious Diseases: ESCMID) (National Institute for Health and Care Excellence: NICE) Meta-analysis (Systematic Review) (Randomized Clinical Trial) Cochrane Library PubMed 2016 12 31 acute bronchitis OR respiratory tract infection OR pharyngitis OR rhinosinusitis OR the common cold Medical Subject Headings (MeSH)

7 Terms OR OR OR OR JAID/JSC IDSA (American College Of Gastroenterology: ACG) (World Gastroenterology Organisation: WGO) diarrhea AND ( acute disease OR infectious diarrhea OR dysentery OR acute gastroenteritis ) MeSH terms OR 4 2.

8 (1) 3 ( ) 7 ( ) 7 9 ( ) 10 (2) ( ) (3)

9 3 Antimicrobial Stewardship 5 ( ) (4) (i) ( ) ( ) 11 12 13 14 (ii)

10 DPT-IPV MR MR 13 23 15 (iii) 16 6 (iv)