13-8 053-066 Technology 香粧品香料の安全性の歴史

1 Technology 4 . IFRA 2. IFRA IFRA SC JFFMA .. TORU ASAKOSHI. 1 IFRA . 1 IFRA CAS No.. Fig leaf absolute 68916-52-9 . Furfuryl alcohol 98-00-0 . 1 4 IFRA. Furfurylidene acetone 623-15-4 . P . R . S . 5146-66-7. 3 Geranyl nitrile 5585-39-7 . 31983-27-4. 2,4-Heptadienal 5910-85-0 . 1 IFRA . trans-2-Heptenal 18829-55-5 .. 2,4-Hexadienal 80466-34-8 . Hexahydrocoumarin 700-82-3 . trans-2-Hexenal diethyl acetal 67746-30-9 . 2011 6 20 IFRA 46 trans-2-Hexenal dimethyl 18318-83-7 . acetal 86 1 . 13393-93-6. Geranyl nitrile Hydroabietyl alcohol, 26266-77-3 . dihydroabietyl alcohol 1333-89-7. Other materials Hydroquinone monoethyl ether 4-ethoxy-Phenol . 622-62-8 . RIFM Hydroquinone monomethyl ether 150-76-5.

2 4-methoxy-Phenol .. RIFM . 5 6 QRA . 2006 11 6 IFRA 41 QRA . Other materials Geranyl Tea leaf absolute 40 2006 5 11. nitrile . 2013 53 965 . 2 IFRA . CAS No.. Musk ketone 81-14-1 Musk xylene . Nootkatone 4674-50-4 Nootkatone 98 32 . Oak moss extracts tree moss . 90028-68-5 Oak moss extracts . Oak moss extracts 9000-50-4 dehydroabieticacid DHA . Oak moss extracts 1000ppm . HPLC. 68917-10-2 atranol chloroatranol oak moss extracts . 100ppm . Pinus Abies genera Pinacea turpentine oil .. Pinacea derivatives delta-3-carene FMA 1 10.. 2 IFRA .. 2 . IFRA 46 . 18 .. 3 IFRA . IFRA 46 100 . 95 .. methyl eugenol . 1 QRA IFRA NOEL . 60kg .. 3 Bergamot oil expressed 7 . NTP . Estragole IFRA 4 . 54 966 2013.

3 Technology 3 . % . CAS No.. 5-Acetyl-1,1,2,3,3,6-hexamethyl indan AHMI 15323-35-0 39 2. Angelica root oil 8015-64-3 39 Bergamot oil expressed 908007-75-8 68916-04-1. Bitter orage peel oil expressed 72968-50-4. Citrus oils and other furocoumarins containing essential oils Bergapten . Cumin oil 8014-13-9 39 . Grapefruit oil expressed 8016-20-4 4. Lemon oil cold pressed 8008-56-8 2. Lime oil expressed 8008-26-2 Methl N- methylanthranilate 85-91-6 44 methyl -naphtyl ketone 93-08-3 39 Rue oil 8014-29-7 91722-29-1. Tagetes oil and absoute 35 8016-84-0. 4 methyl eugenol Estragole . 2 QRA methyl eugenol Estragole 1 % 1 3 Opoponax Styrax Safranal . 2013 47 QRA .. 2013 55 967 . Langerhans Cells LC.

4 2 QRA 2 . Langerhans Cells 1 LC . 25 g/cm2 10 g/. cm2 2 .. 1 2 . induction . 1 . yes 2 1 . induction . 4 . DNCB Sensitization Rate 2 . Site 2. 85%.. DNCB . Local Lymph Node Assay LLNA . Site 8% induction . 1986 Kimber .. Adstracted and amended from Upadhye and Maibach, 1992. 1 . Dose-response . 1 LLNA . induction dose response . 10ug/cm2 25ug/cm2. HRIPT NOEL .. No Migration Migration .. 2 . 56 968 2013 . Technology 5 WoE NESIL 2 . 2006 . LLNA weighted Human Data IFRA WoE NESIL. mean EC3 values NOEL-HRIPT NOEL-MAX LOEL Potency Fragrance lngredient CAS No. Standard g/cm2 . g/cm2 induction induction induction Classification Limit REXPAN NOEL . [no. studies g/cm2 g/cm2 g/cm2 . Extremely 24,000.]

5 -Amylcinnamaldehyde 122-40-7 NA 2942. 3 23,622 NA NA. Weak 23,622 . 3500. -Amylcinnamyl alcohol 101-85-9 NA >6250. 1 3543 NA NA Weak 3543 . Anisyl Alcohol 105-13-5 NA 1475. 1 NA 3448 NA Weak 1500. 5900. Benzyl Alcohol 100-51-6 NA >12,500. 1 5906 6897 8858 Weak 5906 . Extremely 59,000. Benzyl Benzoate 120-51-4 NA >12,500. 1 59,050 20,690 NA. Weak 59,000 . Benzyl Cinnamate 103-41-3 NA 4600. 1 4720 5517 NA Weak 4700. Benzyl Salicylate 118-58-1 NA 725. 1 17,717 20,690 NA Weak 18,000. p-t-Butyl- -methylhydro- 4100. cinnamic aldehyde 80-54-6 2372. 6 4125 NA 29,528 Weak 29,000 . BMHCA . Cinnamyl Alcohol 104-54-1 5250. 1 3000 2759 4724 Weak 3000. 590. Cinnamaldehyde 104-55-2 262. 23 591 NA 775 Moderate 591.

6 Citral 5392-40-5 NA 1414. 11 1400 NA 3876 Weak 1400. Extremely dl-Citronellol 106-22-9 NA 10,875. 1 29,528 4138 NA 30,000. Weak Coumann 91-64-5 NA >6250. 1 3543 5517 8858 Weak 3,500. 5900. Eugenol 97-53-0 2703. 6 5906 NA NA Weak 5900 . 2700. Famesol 4602-84-0 NA 1200. 2 2755 NA 6897 Weak 2700 . Geraniol 106-24-1 NA 3525. 5 11,811 NA NA Weak 12,000. 24,000. -Hexyl-cinnamaldehyde 101-86-0 NA 2372. >5 23,622 NA NA Weak 23,622 . 5000. Hydroxycitronellal 107-75-5 1 5612. 9 5000 NA 5906 Weak 11,811 . 3 4- 4-Hydroxy-4- methylpentyl . 4000. -3-cyclohexene-1- 31906-04-4 4275. 1 4000 NA NA Weak 4,000 . carboxaldehyde HMPCC . 250. lsoeugenol 97-54-1 498. 18 250 NA 775 Moderate 250 . 10,000. d-Limonene 5989-27-5 NA 10,075.

7 5 10,000 5517 NA Weak 5517 . 2013 57 969 . Colipa . Cosmetic Europe CTFA .. PCPC 3 .. 10 .. 3 QRA 2 . 1 3 10 . 1 NESIL No Expected Sensitization Induction . Level .. NESIL induction NOEL .. 2 WoE Weight of Evidence .. SAF . 10.. 3 WoE NESIL 1 3 10.. induction NOEL . 1 3 10. LLNA .. HRIPT .. 5 WoE NESIL . SAF. 4 SAF Sensitization Assessment Factor .. 1 30 100 300 1000.. 3 SAF1 . 58 970 2013 . Technology .. 1 3 6 AEL Acceptable Exposure Level . 10 . WoE . 5 SAF . 3 SAF 3 . SAF 10 30 100 300 1000. WoE NESIL. 300 AEL =.. SAF 6 . SAF 7 300 7 CEL Consumer Exposure Level .. 100 . 8 QRA . 10 QRA . 6 SAF 7 QRA . SAF IFRA 4 . Citral . SAF 10 SAF 3 SAF 10 300. WoE NESIL. 1400 g/cm2. WoE .. SAF 100.

8 10 3 3 .. AEL . g/cm2. WoE NESIL/SAF . SAF 10 SAF 3 SAF 3 100 CEL . 4 .. AEL/CEL g/cm2 . AEL/CEL . SAF 10 SAF 1 SAF 1 10 . AEL _ CEL . _ . citral . Citral .. 2013 59 971 . 8 IFRA . IFRA QRA SAF .. mg/cm2/ . 1 300 . 2 300 . 3 300 .. 4 100 . 5 100 / . 6 100 . 7 300 . 8 100 . 9 100 .. 10 100 .. 11 10 . AEL/CEL . AEL CEL 2 . 8 . 7 . Citral IFRA QRA 4 5 . IFRA . QRA . CEL QRA. 39 .. QRA methyl eugenol estragole .. 4 9 . QRA IFRA . SAF 46 11 23 . 60 972 2013 . Technology 7 QRA . 2 RIFM 4 1 .. QRA JRC IDEA. QRA . SAF .. 2 RIFM 4 4 . aggregate exposure .. IFRA/. RIFM 2 QRA . 3 . 4 QRA . 2011 12 . SCCS . 2012 7 . 6 QRA SCCS . IFRA QRA European Commission DG. 4 QRA SANCO . RIFM IFRA .. 10 . RIFM/ 1 HICC Lyral.

9 IFRA QRA IFRA atranol chloroatranol 2 100ppm . QRA 11 26 .. 2013 61 973 . 3 . DG SANCO 1 3 . IFRA . DG SANCO 82 .. IFRA QRA . IFRA .. IDEA QRA . IFRA .. IFRA sound .. atranol . chloroatranol . atranol chloroatranol . Oakmoss treemoss . 17 3 .. 9 IFRA . IFRA39 estrgole IFRA. methyleugeno . QRA .. 1.. 4ppm .. 4ppm 4ppm 2.. 4ppm 2.. 4ppm 2. 62 974 2013 . Technology IFRA39 estrgole IFRA. methyleugeno . QRA .. 3. 80ppm JFFMA .. 200ppm .. 4ppm . 4ppm 4ppm 4ppm 4ppm 4. 80ppm . 200ppm . 4ppm .. 4ppm . 40ppm 80ppm 4ppm Scent Pads . Foil Packs 80ppm 80ppm 4ppm 4ppm . for adults . 4ppm . 5 . / 4ppm 5. 4ppm 5. 5.. 4ppm 5 . 4ppm 5.. 4ppm 5.. 4ppm 5. 4ppm 5. 6.. 10ppm . 6. 10ppm . 6. 7. 4ppm 4ppm 4ppm 8.

10 4ppm 2013 63 975 . IFRA39 estrgole IFRA. methyleugeno . QRA .. 4ppm . 4ppm .. 4ppm . 10ppm 9.. 10ppm 10ppm .. 10ppm 10ppm .. 10ppm 10ppm .. 10ppm . 10ppm . , 10ppm . , . 10ppm .. 10ppm .. 10ppm .. Wheat bags 10ppm .. 10ppm .. 10.. 10ppm .. 4ppm 10ppm . 10ppm . 4ppm 11. 200ppm/.. 64 976 2013 . Technology IFRA39 estrgole IFRA. methyleugeno . QRA .. 10ppm . 200ppm/.. 200ppm/.. 200ppm/. AirDeliveryStstems .. 10ppm . reed diffuser, . 200ppm/.. 10ppm . / .. 10ppm . 200ppm/.. 200ppm/.. 200ppm/.. 200ppm/.. 200ppm/.. 10ppm . 200ppm/. liquitabs ** . 200ppm/.. 200ppm/.. 200ppm/.. 10ppm . 200ppm/. scent pack . 200ppm/.. 10ppm .. 10ppm .. 10ppm . 2013 65 977 . IFRA39 estrgole IFRA. methyleugeno.