2 ホルムアルデヒド曝露作業者の ... - zsisz.or.jp

1 43 SUMCO 37 20 3 CO2 GC GCMS HPLC 1 ( ) 3 3 ( )

2 1 19 1495ug/m3 1ppm 4 2 120 g/m3 153 g/m3 14 38 mg/gCr 10 33 mg/gCr 45 30 118 195 37 2004 20 3 CO2 GC GCMS HPLC 1 A( ) 3 B C D 3 E F G( ) DSD-DNPH 1 HPLC Prominance UFLC ( )

3 Shim-pack XR-ODS ( 75mm ) A DW B:CH3CN ml/min 0% 55% 55% 35% stop 50 C 360nm 4ul -DNPH 10 g/ml 018-18231 Uptake rate ppb x 25 C Ya s u g i GC Shimadzu GC-17A HSS-4A 1ml 2ml 1ml HSS-4A 60 C 30min GC DB-WAX ( x 60m J W) 46 GC 60 C ( ) 150 C 200 C He 20ml/min ( ) A 30 B C D 1 E F G 1 HPLC 19 1495ug/m3 GC 2 14 38 mg/gCr 10 33 mg/gCr 47 DNPH HPLC GC ( )

4 48 A G HCHO g/m3 mg/gCr 149513 19 28 24 103812 27 20 19 26817 14 28122 16 2923 18 3221 18 5819 19 3219 22 9419 24 2424 18 3120 23 3424 21 15322 25 1918 20 8123 15 10 4826 38 4325 15 5 4521 15 10 4122 30 50 5731 4215 5133 3632 4725 6218 30 3913 20 5114 20 3914 25 5010 3 0 5 15 3 0 120 90 15 30 EFG ABCD 49 (120 g/m3)

5 A 1ppm B 4 2 120 g/m3 D 1 B C D E F G 30 2003 10 20 12 11 HPLC 2 30 16 7 CO2 GSH-dependent FA dehydrogenase Ya s u g i mg/l (n=79) (n=70) Berode 12 mg/ Cr ( ) 14 38 mg/gCr 10 33 mg/gCr GC GCMS HPLC Takeuchi GC ECD o-(2,3,4,5,6-pentafluorobenzyl)hydroxyla mine / HPLC 13 1ppm ppm 140 g/l g/l 14)

6 15 Coasta ppm ( ) 50 16 51 1. 2007;49(4) 175-181 2. 3. Conaway CC, Whysner J, Verna LK, Williams GM. Formaldehyde mechanistic data and risk assessment: endogenous protection from DNA adduct formation.

7 Pharmacol Ther. 1996;71(1-2):29-55. 4. Gottschling LM, Beaulieu HJ, Melvin WW. Monitoring of formic acid in urine of humans exposed to low levels of formaldehyde. Am Ind Hyg Assoc J. 1984 Jan;45(1):19-23. 5. Boeniger MF. Formate in urine as a biological indicator of formaldehyde exposure: a review. Am Ind Hyg Assoc J. 1987 Nov;48(11):900-8 6. Heinzow B, Ellrott T. [Formic acid in urine--a significant parameter in environmental diagnosis?][Article in German English abstract] Zentralbl Hyg Umweltmed. 1992 Feb;192(5):455-61. 7. Schmid K, Schaller KH, Angerer J, Lehnert G. [The importance of formic acid excretion in the urine for environmental and occupational medicine questions][Article in German English abstract] Zentralbl Hyg Umweltmed. 1994 Aug;196(2):139-52. 8. Takeuchi A, Takigawa T, Abe M, Kawai T, Endo Y, Yasugi T, Endo G, Ogino K. Determination of formaldehyde in urine by headspace gas chromatography. Bull Environ Contam Toxicol.

8 2007 Jul;79(1):1-4. 9. Yasugi T, Kawai T, Mizunuma K, Horiguchi S, Iwami O, Iguchi H, Ikeda M. Formic acid excretion in comparison with methanol excretion in urine of workers occupationally exposed to methanol. Int Arch Occup Environ Health. 1992;64(5):329-37. 10.. 2004; 11. , , , , , , .. 2008 56(5) 198-201 12. Berode M, Sethre T, L ubli T, Savolainen H. Urinary methanol and formic acid as indicators of occupational exposure to methyl formate. Int Arch Occup Environ Health. 2000;73(6):410-4. 13. , , , , , , .. 2006; 4: 249 14. , , , , , , , .. 2007;49:824 15. , , , , .. 2008;63:452 16. Costa S, Coelho P, Costa C, Silva S, Mayan O, Santos LS, Gaspar J, Teixeira JP. Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde. Toxicology.

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