2018年6月11日 - jscb.jp

1 2018 6 11 9:45 9:50 9:50 09:55 13 09:55 12:00 S-01 10:00 10:30 Chemosensory signals regulating animal behavior: biological chemistry or chemical biology? 1,2) Kazushige Touhara1,2) 1) 2)ERATO 1)Department of Applied Biological Chemistry, The University of Tokyo, 2)ERATO Touhara Chemosensory Signal Project, JST S-02 10:30 11:00 Are fairy chemicals a new family of plant hormone? Hirokazu Kawagishi Research Institute of Green Science and Technology, Shizuoka University S-03 11:00 11:30 Small-molecule degraders via selective autophagy Hirokazu Arimoto Graduate School of Life Sciences, Tohoku University S-04 11:30 12:00 Peptide-mediated delivery of bioactive molecules into cells Shiroh Futaki Institute for Chemical Research, Kyoto University 12:00 13:00 A 13:00 15:30 O-01 13:00 13.

2 15 -F Enhancement of intracellular proteasome inhibition and drug-resistant cell death induction by cell-penetrating peptides conjugation to Ridaifen-F 1) 1) 1) 2) 2) 2) 2) 1) 1) 2) 1) Makoto Tanaka1), Yunhao Zhu1), Masafumi Shionyu1), Nozomi Ota2), Natsumi Shibata2), Chihiro Watanabe2), Akihito Mizusawa2), Ryuzo Sasaki1), Tamio Mizukami1), Isamu Shiina2), Makoto Hasegawa1) 1) 2) 1)Faculty of Bioscience, Nagahama Institute of Bio-Science and Technology, 2)Department of Applied Chemistry, Faculty of Science, Tokyo University of Science O-02 13:15 13:30 Antibody-synthetic polymer hybrid sensing materials for intact exosomes Kisho Mori, Eri Takano, Yukiya Kitayama, Toshifumi Takeuchi Graduate School of Engineering, Kobe University O-03 13:30 13.

3 45 PILR gB Effect of sugar chain on interaction of HSV-1 Glycoprotein with immune receptor PILR 1) 2) 3) 2) 2) 2) 4) 1,3) Takao Nomura1), Kosuke Kakita2), Atsushi Furukawa3), Masahiro Anada2), Shunichi Hashimoto2), Shigeki Matsunaga2), Takashi Saitoh4), Katsumi Maenaka1,3) 1) 2) 3) 4) 1)Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, 2)Laboratory of Synthetic and Industrial Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, 3)Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, 4)School of Pharmacy, Hokkaido Pharmaceutical University O-04 13:45 14.

4 00 SIRT2- X SIRT2 X-ray crystal structure analysis of a SIRT2-inhibitor complex and structure-based drug discovery studies on SIRT2-selective inhibitors 1) Paolo Mellini1) 2) 1) 1) 3) 4) 2) 3) Maija Lahtela-Kakkonene5) 1) Yukihiro Itoh1), Paolo Mellini1), Hiroki Tsumoto2), Ying Li1), Miki Suzuki1), Natsuko Tokuda3), Taeko Kakizawa4), Yuri Miura2), Jun Takeuchi3), Maija Lahtela-Kakkonene5), Takayoshi Suzuki1) 1) 2) 3) 4) 5) 1)Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 2)Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, 3)Minase Research Institute, Ono Pharmaceutical Co.

5 , Ltd. 4)Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, 5)School of Pharmacy, University of Eastern Finland O-05 14:00 14:15 NMR GOLD virtual screening NMR-derived docking performance index facilitates virtual screening using GOLD suite 1) 2) 1) 1,3) 4) 5) 1,3) Kiminori Hori1), Kasumi Ajioka2), Natsuko Goda1), Takeshi Tenno1,3), Maki Takagishi4), Asako Shindo5), Hidekazu Hiroaki1,3) 1) 2) 3) BeCellBar 4) 5) 1)Graduate School of Pharmaceutical Sciences, 2)School of Science, 4)Graduate School of Medicine, 5)Division of Biological Science, Graduate School of Science, Nagoya University, 3)BeCellBar LLC.

6 O-06 14:15 14:30 Studies of enantioselective biological activities of thalidomide and fluorothalidomide including multiple myeloma, angiogenesis, and teratogenicity Etsuko Tokunaga, Norio Shibata Nagoya Institute of Technology O-07 14:30 14:45 Development of antidotes against organophosphorus nerve agents Kazunori Koide Department of Chemistry, University of Pittsburgh O-08 14:45 15:00 GPCR Drug discovery by re-searching cancer metabolism and GPCR signaling 1) 2) 1) 1) 1) 1) Francois Marie Ngako Kadji2) 2) 1) 3) 2) 3) 1) Masayasu Toyomoto1), Asuka Inoue2), Kei Iida1), Masatsugu Denawa1), Isao Kii1), Keiko Hayashi1), Francois Marie Ngako Kadji2), Takayuki Kishi2), Hiroshi Onogi1), Suguru Yoshida3), Junken Aoki2), Takamitsu Hosoya3), Masatoshi Hagiwara1) 1) 2) 3) 1)Graduate School of Medicine, Kyoto University, 2)Graduate School of Pharmaceutical Sciences, Tohoku University, 3)

7 Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University O-09 15:00 15:15 Discovery of pre-saccharothriolide X from the rare actinomycete Saccharothrix sp. Shan Lu1), Shinichi Nishimura1,3), Masashi Ito2), Taira Kato2), Hideaki Kakeya1) 1)Grad. Sch. Pharm. Sci., Kyoto Univ., 2)MBJ, 3)Univ. of Tokyo (present) O-10 15:15 15:30 Synthetic molecules for regulating ADCC Synthetic alternative of therapeutic antibody 1) 1) 1) 1,2) 1,2) 1,2,3,4) Koichi Sasaki1), Yoshiki Miyashita1), Minori Harada1), Akihiro Kishimura1,2), Takeshi Mori1,2), Yoshiki Katayama1,2,3,4) 1) 2) 3) 4)Chung Yuan Christian University 1)Dept Applied Chemistry, Faculty of Engineering, Kyushu Univ.

8 2)Center of Molecular Systems, Kyushu Univ. 3)Center for Advanced Medical Innovation, Kyushu Univ. 4)Chung Yuan Christian University 15:30 15:40 B 15:40 17:40 O-11 15:40 15:55 HIV Development of an artificial phosphoinositide derivative aiming at HIV eradication 1) 2) 1) 1,3) 1) 4) Hiroshi Tateishi1), Kensaku Anraku2), Ryoko Koga1), Halil Ciftci Ibrahim1,3), Masami Otsuka1), Mikako Fujita4) 1) 2) 3) 4) 1)Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, 2)Department of Medical Technology, Kumamoto Health Science University, 3)Science Farm Ltd.

9 , 4)Research Institute for Drug Discovery, School of Pharmacy, Kumamoto University O-12 15:55 16:10 HomoFluoppi STAT3 Development of a novel method for analysis of dynamic STAT3 homodimerization in living cells using homoFluoppi 1,2) 3) 3) 1) 1) 1) Yusuke Okada1,2), Taku watanabe3), Toru Shoji3), Kyoko Taguchi1), Naohisa Ogo1), Akira Asai1) 1) 2) 3) 1)Centre for Drug Discovery, Graduate Division of Pharmaceutical Science, University of Shizuoka, 2)Discovery Technology Laboratories, Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 3)Ina Laboratory, Medical & Biological Laboratories Co.

10 , Ltd. O-13 16:10 16:25 AFM Amyloid 1-42 Observation of growing amyloid protofibrils 2D network with high speed AFM 1) 1) 2) 2,3) 2,3) Ryu Tashiro1), Hiroaki Taguchi1), Kumi Hidaka2), Masayuki Endo2,3), Hiroshi Sugiyama2,3) 1) 2) 3) iCeMS 1)Faculty of Pharmaceutical Sciences, Suzuka University of Medical Sciences, 2)Department of Chemistry, Graduate School of Science, Kyoto University, 3)Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University O-14 16:25 16:40 CD DNA - Development of the time-resolved high sensitive CD measurement system for detection of biomolecular dynamics - Toward the high sensitive detection of interaction dynamics of dsDNA and TMPyP - 1) 1) 1) 1) 2) 2) 1) Takehiko Wada1), Makoto Kuronuma1), Makoto Murakami1), Masaki Nishijima1), Satoru Ishibashi2), Takanori Yokota2), Yasuyuki Araki1) 1) 2) 1)Institute of Multidisciplinary Research for Advanced Material (IMRAM), Tohoku University, 2)