2018 CPT Code Changes Cytopathology CPT Code …

1 CPT CodeNew/Revised/DeletedDescriptionG0364 DeletedBone marrow aspirate & biopsy38222 NewDiagnostic bone marrow; biopsy(ies) and aspirations(s)88154 Deletedwith manual screening and computer-assisted rescreening using cell selection and review under physician supervisionCPT CodeNew/Revised/DeletedDescription82043 Revisedurine (eg, microalbumin), quantitative82044 Revisedurine (eg, microalbumin), semiquantitative (eg, reagent strip assay)82042 Revisedother source, quantitative, each specimen83499 DeletedHydroxyprogesterone, 20-84061 Deletedforensic examinationCPT CodeNew/Revised/DeletedDescription86003 RevisedAllergen specific IgE; quantitative or semiquantitative, crude allergen extract, each86005 Revisedqualitative, multiallergen screen (eg, disk, sponge, card)86008 NewAllergen specific IgE; quantitative or semiquantitative, recombinant or purified component, each86185 DeletedCounterimmunoelectrophoresis, each antigen86243 DeletedFc receptor86378 DeletedMigration inhibitory factor test (MIF)86729 Deletedlymphogranuloma venereum86794 NewZika virus, IgMCPT CodeNew/Revised/DeletedDescription86822 Deletedlymphocyte culture, primed (PLC)CPT CodeNew/Revised/DeletedDescription87277 DeletedLegionella micdadei87470 DeletedInfectious agent detection by nucleic acid (DNA or RNA); Bartonella henselae and Bartonella quintana, direct probe technique2018 CPT Code ChangesCytopathology Chemistry Immunology Tissue TypingMicrobiology87477 DeletedBorrelia burgdorferi, quantification87515 Deletedhepatitis B virus, direct probe technique87634 NewInfectious agent detection by nucleic acid (DNA or RNA).

2 Respiratory syncytial virus, amplified probe technique87662 NewInfectious agent detection by nucleic acid (DNA or RNA); Zika virus, amplified probe techniqueCPT CodeNew/Revised/DeletedDescriptionG0499 NewHepatitis B screening in non-pregnant, high risk individual includes hepatitis B surface antigen (HBsAg) followed by a neutralizing confirmatory test for initially reactive results, and antibodies to HBsAg (anti-HBs) and hepatitis B core antigen (anti-HBc)CPT CodeNew/Revised/DeletedDescription81175 NewASXL1 (additional sex combs like 1, transcriptional regulator) (eg, myelodysplastic syndrome, myeloproliferative neoplasms, chronic myelomonocytic leukemia) gene analysis; full gene sequence81176 NewASXL1 (additional sex combs like 1, transcriptional regulator) (eg, myelodysplastic syndrome, myeloproliferative neoplasms, chronic myelomonocytic leukemia) gene analysis.

3 Targeted sequence analysis (eg, exon 12)81230 Newwas 81401 CYP3A4 (cytochrome P450 family 3 subfamily A member 4) (eg, drug metabolism) gene analysis, common variant(s) (eg, *2, *22)81231 Newwas 81401 CYP3A5 (cytochrome P450 family 3 subfamily A member 5) (eg, drug metabolism) gene analysis, common variants (eg, *2, *3, *4, *5 *6, *7)81232 Newwas 81400 DPYD (dihydropyrimidine dehydrogenase) (eg, 5-fluorouracil/5-FU and capecitabine drug metabolism) gene analysis, common variant(s) (eg, *2A, *4, *5, *6)81238 Newwas 81405F9 (coagulation factor IX) (eg, hemophilia B) full gene sequence81247 NewG6PD (glucose-6-phosphate dehydrogenase) (eg, hemolytic anemia, jaundice) gene analysis; common variant(s) (eg, A, A-)81248 NewG6PD (glucose-6-phosphate dehydrogenase) (eg, hemolytic anemia, jaundice) gene analysis; known familial variant(s)81249 NewG6PD (glucose-6-phosphate dehydrogenase) (eg, hemolytic anemia, jaundice) gene analysis; full gene sequence Tier 1 Molecular Pathology Other81257 RevisedHBA1/HBA2 (alpha globin 1 and alpha globin 2)(eg, alpha thalassemia , Hb Bart hydrops fetalis syndrome, HbH disease), gene analysis; common deletions or variant (eg, Southeast Asian, Thai, Filipino, Mediterranean, , , , and Constant Spring)81258 NewHBA1/HBA2 (alpha globin 1 and alpha globin 2) (eg, alpha thalassemia , Hb Bart hydrops fetalis syndrome, HbH disease), gene analysis; known familial variant81259 Newwas 81405 HBA1/HBA2 (alpha globin 1 and alpha globin 2) (eg, alpha thalassemia , Hb Bart hydrops fetalis syndrome, HbH disease), gene analysis.

4 Full gene sequence81269 Newwas 81404 HBA1/HBA2 (alpha globin 1 and alpha globin 2) (eg, alpha thalassemia , Hb Bart hydrops fetalis syndrome, HbH disease), gene analysis; duplication/deletion variants81105 Newwas 81400 Human Platelet Antigen 1 genotyping (HPA-1), ITGB3 (integrin, beta 3 [platelet glycoprotein IIIa], antigen CD61 [GPIIIa]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura) gene analysis, common variant, HPA-1a/b (L33P)81106 Newwas 81400 Human Platelet Antigen 2 genotyping (HPA-2), GP1BA (glycoprotein Ib [platelet], alpha polypeptide [GPIba]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura) gene analysis, common variant, HPA-2a/b (T145M)81107 Newwas 81400 Human Platelet Antigen 3 genotyping (HPA-3), ITGA2B (integrin, alpha 2b [platelet glycoprotein IIb of IIb/IIIa complex], antigen CD41 [GPIIb]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura)

5 Gene analysis, common variant, HPA-3a/b (I843S)81108 Newwas 81400 Human Platelet Antigen 4 genotyping (HPA-4), ITGB3 (integrin, beta 3 [platelet glycoprotein IIIa], antigen CD61 [GPIIIa]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura) gene analysis, common variant, HPA-4a/b (R143Q)81109 Newwas 81400 Human Platelet Antigen 5 genotyping (HPA-5), ITGA2 (integrin, alpha 2 [CD49B, alpha 2 subunit of VLA-2 receptor] [GPIa]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura) gene analysis, common variant (eg, HPA-5a/b (K505E))81110 Newwas 81400 Human Platelet Antigen 6 genotyping (HPA-6w), ITGB3 (integrin, beta 3 [platelet glycoprotein IIIa, antigen CD61] [GPIIIa]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura) gene analysis, common variant, HPA-6a/b (R489Q)81111 Newwas 81400 Human Platelet Antigen 9 genotyping (HPA-9w), ITGA2B (integrin, alpha 2b [platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41] [GPIIb]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura) gene analysis, common variant, HPA-9a/b (V837M)81112 Newwas 81400 Human Platelet Antigen 15 genotyping (HPA-15), CD109 (CD109 molecule) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura) gene analysis, common variant, HPA-15a/b (S682Y)81120 Newwas 81403 IDH1 (isocitrate dehydrogenase 1 [NADP+], soluble) (eg, glioma), common variants (eg, R132H, R132C)81121 Newwas 81403 IDH2 (isocitrate dehydrogenase 2 [NADP+], mitochondrial) (eg, glioma), common variants (eg, R140W, R172M)

6 81283 Newwas 81400 IFNL3 (interferon, lambda 3) (eg, drug response) gene analysis, rs12979860 variant81334 NewRUNX1 (runt related transcription factor 1) (eg, acute myeloid leukemia, familial platelet disorder with associated myeloid malignancy) gene analysis, targeted sequence analysis (eg, exons 3-8)81328 Newwas 81400 SLCO1B1 (solute carrier organic anion transporter family, member 1B1) (eg, adverse drug reaction) gene analysis, common variant(s) (eg, *5)81335 Newwas 81401 TPMT (thiopurine S-methyltransferase) (eg, drug metabolism) gene analysis, common variants (eg, *2, *3)81346 Newwas 81401 TYMS (thymidylate synthetase) (eg, 5-fluorouracil/5-FU drug metabolism) gene analysis, common variant(s) (eg, tandem repeat variant)81361 Newwas 81401 HBB (hemoglobin, subunit beta) (eg, sickle cell anemia, beta thalassemia , hemoglobinopathy); common variant(s) (eg, HbS, HbC, HbE)81362 Newwas 81401 HBB (hemoglobin, subunit beta) (eg, sickle cell anemia, beta thalassemia , hemoglobinopathy); known familial variant(s)81363 Newwas 81403 HBB (hemoglobin, subunit beta) (eg, sickle cell anemia, beta thalassemia , hemoglobinopathy); duplication/deletion variant(s)81364 Newwas 81404 HBB (hemoglobin, subunit beta) (eg, sickle cell anemia, beta thalassemia , hemoglobinopathy).

7 Full gene sequenceCPT CodeNew/Revised/DeletedDescriptionRevise dnow 81232 DPYD (dihydropyrimidine dehydrogenase) (eg, 5-fluorouracil/5-FU and capecitabine drug metabolism), IVS14+1G>A variantRevisednow 81105 Human Platelet Antigen 1 genotyping (HPA-1), ITGB3 (integrin, beta 3 [platelet glycoprotein IIIa], antigen CD61 [GPIIIa]) (eg,neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura), HPA-1a/b (L33P)Revisednow 81106 Human Platelet Antigen 2 genotyping (HPA-2), GP1BA (glycoprotein Ib [platelet], alpha polypeptide [GPIba]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura), HPA-2a/b (T145M)Revisednow 81107 Human Platelet Antigen 3 genotyping (HPA-3), ITGA2B (integrin, alpha 2b [platelet glycoprotein IIb of IIb/IIIa complex], antigen CD41 [GPIIb]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura), HPA-3a/b (I843S)Revisednow 81108 Human Platelet Antigen 4 genotyping (HPA-4), ITGB3 (integrin, beta 3 [platelet glycoprotein IIIa], antigen CD61 [GPIIIa]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura), HPA-4a/b (R143Q)Revisednow 81109 Human Platelet Antigen 5 genotyping (HPA-5), ITGA2 (integrin, alpha 2 [CD49B, alpha 2 subunit of VLA-2 receptor] [GPIa]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura), HPA-5a/b (K505E)Revisednow 81110 Human Platelet Antigen 6 genotyping (HPA-6w), ITGB3 (integrin, beta 3 [platelet glycoprotein IIIa, antigen CD61] [GPIIIa]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura), HPA-6a/b (R489Q)

8 Revisednow 81111 Human Platelet Antigen 9 genotyping (HPA-9w), ITGA2B (integrin, alpha 2b [platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41] [GPIIb]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura), HPA-9a/b (V837M)RevisedMolecular pathology procedure, Level 2 (eg, 2-10 SNPs, 1 methylated variant, or 1 somatic variant {typically using nonsequencing target variant analysis}, or detection of a dynamic mutation disorder/triplet repeat)Revisednow 81230 CYP3A4 (cytochrome P450, family 3, subfamily A, polypeptide 4) (eg, drug metabolism), common variants (eg, *2, *3, *4, *5, *6)Revisednow 81231 CYP3A5 (cytochrome P450, family 3, subfamily A, polypeptide 5) (eg, drug metabolism), common variants (eg, *2, *3, *4, *5, *6)Tier 2 Molecular Pathology 81400 RevisedMolecular pathology procedure, Level 1 (eg, identification of single germline variant [eg, SNP] by techniques such as restriction enzyme digestion or melt curve analysis)81401 Revised now 81361 & 81362 HBB (hemoglobin, beta) (eg, sickle cell anemia, hemoglobin C, hemoglobin E), common variants (eg, HbS, HbC, HbE)Revisednow 81335 LINC00518 (long intergenic non-protein coding RNA 518) (eg, melanoma), expression analysisRevisednow 81346 PRAME (preferentially expressed antigen in melanoma) (eg, melanoma), expression analysisTPMT (thiopurine S-methyltransferase) (eg, drug metabolism), common variants (eg, *2, *3)TYMS (thymidylate synthetase) (eg, 5-fluorouracil/5-FU drug metabolism)

9 , tandem repeat variantRevised Molecular pathology procedure, Level 4 (eg, analysis of single exon by DNA sequence analysis, analysis of >10 amplicons using multiplex PCR in 2 or more independent reactions, mutation scanning or duplication/deletion variants of 2-5 exons)Revised now 81363 HBB (hemoglobin, beta, beta-globin) (eg, beta thalassemia ), duplication/deletion analysisRevisednow 81120 IDH1 (isocitrate dehydrogenase 1 [NADP+], soluble) (eg, glioma), common exon 4 variants (eg, R132H, R132C)Revisednow 81121 IDH2 (isocitrate dehydrogenase 2 [NADP+], mitochondrial) (eg, glioma), common exon 4 variants (eg, R140W, R172M)RevisedMolecular pathology procedure, Level 5 (eg, analysis of 2-5 exons by DNA sequence analysis, mutation scanning or duplication/ deletion variants of 6-10 exons, or characterization of a dynamic mutation disorder/triplet repeat by Southern blot analysis)Revisednow 81269 HBA1/HBA2 (alpha globin 1 and alpha globin 2) (eg, alpha thalassemia ), duplication/deletion analysisRevisednow 81364 HBB (hemoglobin, beta, Beta-Globin) (eg, thalassemia ), full gene sequenceRevisedMolecular pathology procedure, Level 6 (eg, analysis of 6-10 exons by DNA sequence analysis, mutation scanning or duplication/deletion variants of 11-25 exons, regionally ta)