亜鉛欠乏症の診療指針2018 Reserved. - jscn.gr.jp

1 1 2003 23 2016 38 2 104-148, 2016. Wilson 2017 3 2018 2018 JSCN.

2 All Rights Reserved. 2 3 I. II. III. IV. V. VI. VII. VIII. IX. X. XI. 1. 1 1 2 ALP 2.

3 3. 3-1 60 g/dL 3-2 60 80 g/dL 4. Probable 1 2 3 Definite 1 2 3-1 4 1 2 3-2 4 50 100mg/ 1 3mg/kg/ 20kg 25mg/ 20kg 50mg/ 2 1 250 g/dL I 20 40%

4 2018 JSCN. All Rights Reserved. 4 5 2 80% 20% 3% 14 ZIP 10 ZnT 60% 20 30% 8% 4 6% 1. 1,2 20 40% 3 Zrt/Irt ZIP4 ZnT1 4-7 8 14 3 15 C 357nmol/L/ /40cm 230nmol/L/ /40cm 84nmol/L/ /40cm 1 2 16 3 17 18 2 SLC30 ZnT SLC39 ZIP

5 19 20 ZIP 1 ZIP4 6 21 ZIP Zrt-, Irt-like protein, SLC39A ZnT Zn transporter, SLC30A 1 ZnT 9 ZIP 14 1, 2 ZIP Z n T 23 1 ZIP SLC39A ZnT SLC30A 1 Zip Zip Zip1 Zip2 Zip3 Zip4 apical Zip5 b a s o - l a t e r a l Zip6 Zip7 Zip8 apical Zip9 Zip10 Zip11 Zip12 Zip13 Zip14 apical 23 2 ZnT ZnT ZnT1 ZnT2 ZnT3 ZnT4

6 ZnT5 ZnT6 ZnT7 ZnT8 ZnT10 ZnT 9 HUEL/GAC63 coactivator 23 ZIP SLC39A ZnT SLC30A MTF-1 Z n T 1 Z n T 1 ZIP ZnT1 23 2 ZIP SLC39A ZIP SLC39A MTF-1 ZnT1 MT MT ZnT1 Zn2 Zn2 Zn2 Zn2 Zn2 Zn2 Zn2 Zn2 Zn2 Zn2 Zn2 MT Zn2 Zn2 MT ZnT1 2018 JSCN.

7 All Rights Reserved. 6 7 4 6 22 23 2 3 5 10mg/ 24 26 5 g/mL 27 Spencer 18% 45 28 Matseshe 25 35% 29 Neve 45mg 70% 17 30 31 32 4 70kg 3g 60% 20 30% 8% 4 6% 1% 33 34

8 27 35 36 80% 20% 3% 60 80% 2- 33 37 40 40 42 43 3% 2 44 23 24 22 g/g g/g g/g 45 5 28 16 46 65Zn 322 28 280 33 65Zn 5mg/kg 52 160mg/kg 4 47 II 2015 48 10mg/ 8mg/ 2mg/ 3mg/ 3 0 5 780mL/ 780mL/ 2010 2mg/ 3 mg/ 0 5 2 2 6 1 1 3 3 1 2 33 33 3 5 34 34 6 7 45 45 8 9 56 55 1 0 1 1 67 67 12 14 89 78 1 5 1 7 910 68 1 8 2 9 8104068353 0 4 9

9 81045683550 6 9 81045683570 89406735 +1+2 +3+3 2015 48 4 1 6 7 14 15 19 20 29 30 39 40 49 50 59 60 69 70 19 23 1973141752733684564556388083,684 mg/ mg/ 3 55 91010101010109 117295 162 284 420 533 506 770 970 4,117 116 252 mg/ mg/ 3 55 888888871011 27 19 23 2015 2018 JSCN. All Rights Reserved. 8 9 27 3 49 20 4 III 300 DNA RNA CA ALP ADH SOD OTC 300 5 50 A A 51 52 zinc finger protein 53

10 54 55-57 IV DNA zinc finger protein 1 8 58 ATP ATP 59 60 2 zinc finger protein GATA-1 61 TIBC 62,63 3 cyclic AMP phosphodiesterase