⾷物経⼝負荷試験の⼿引き2020 - foodallergy.jp

1 2020 NPO 2020 Copyright 2020 2020.

2 All rights reserved 2 4 10 13 20 1 2 3 4 5 6 3 2020 2020 1 2 3 3 1 2 3 4 5 6 7 8 9 DBV Technologies EPD oral food challenge, OFC OFC 2.

3 2019;33:726-37 . 2019;33:106-16 Bird JA, et al. J Allergy Clin Immunol Pract 2020;8:75-90 1. 2. 3. 1. 2. 1 OFC 4 2021 1. 2. 3.

4 1. IgE 2. 1. 2. 3. 2 OFC 2 OFC OFC 3 3 1 OFC OFC OFC

5 OFC OFC Yanagida et al. J Allergy Clin Immunol Pract 2018;6 . 2018;32:776-84 . 2019;33:129-38 5 (low dose) 1/32 1/25 1 3mL 1 (mediumdose) 1/8 1/2 4 18g10 50mL 10 50g1 5 (full dose) 30 50 (2/3~1 ) 25 35g100 200mL 100 200g6 1/2 1 10 3 1 M 2 3 30 1 2.

6 2008;57:1043-52 . 2011;25:785-93 Yanagida N, et al. World Allergy Organ J 2016;9:12 Yanagida N, et al. Pediatr Allergy Immunol 2021;32:170-66120 120 120 60 30 60 30 60 3 2 1/43/41/83/84/8 OFC 1 3 2 4 2021( ) 1 2 3 SpO2 92% 15 / 1 < 70mmHg1 10 < [70 + (2 )] mmHg11 < 90mmHg 1 < 80mmHg1 10 < [80 + (2 )]

7 ] mmHg11 < 100mmHg7 2 3 2 3 2 H1 2 2 10L/ 30cm 10mL/kg 5 10 5 15 1 g/kg/ (kg) 20mL 2mL/ g/kg/ 1mg/kg (1mL/kg) 5 10mg/kg 1mg/kg 60mg/ 1mg/mL ( )1 12 ( )12 L( ) 2021( )

8 2 3 2 8 OFC 80% 99% OFC 1 OFC Miura T, et al. Pediatr Allergy Immunol. 2018;29:66-79 OFC Yanagida N, et al.

9 Pediatr Allergy Immunol 2021;32:170-6 OFC 6 OFC OFC OFC OFC OFC OFC 2 OFC 1 OFC OFC 6 OFC OFC

10 1 2 OFC OFC et al. Asia Pac Allergy 2017;7:234-42 10 OFC 9 2 1000 DPC 5 1. 2. 10 1 3. 5 DPC DPC 9 2 39 3 OFC ( )