Transcription of 22．膠原病又はその類縁疾患 - jslm.org
1 22 .. ( ) ( RA . (RA) SLE SSc . (SLE) ( PSS SSc ) ) ( . (PM-DM) (PN) ) . (RF) 6 1) .. (MCTD) 1 .. 1) .. ( 1) ( . ( ) ( ) CH50 . ) ( ) 2)( 1). ( ) ( 1 . ) ( . ) . ( ).. 1 ( 1). ) ( ). ) ( 1). ) . ) ( CRP) 1 .. )X ( ) 2 . ) . 2 . ) (RF). ) (FANA). )CH50. 1 . 1 ( ).. ( ) . (pH ) . ( ) RBC Hb Ht . WBC WBC .. : APTT PT. ( ) [AST ALT . LD ALP GT CK] . [UN ] ( . TG HDL-C) (Na K Cl) . ( ) X ( ) . 96 . 22 . 2 . 1) CRP SAA. 2) ( 1) (G A M) C3 C4. ( 2). 3) *. X ( ). CT MRI. 4) *.. * . CH50 3) . CRP SLE CRP ( 2) . A(SAA) CRP . SAA RF . SS-A SS-B .. (RF) (FANA).. SSA, CH50 (PPD . RF* dsDNA Sm U1 RNP Scl70 Jo1 . SSB ). (aCL LA). RA IgGRF. #1 mRF . SLE . #2 Clq . (VDR) . LE . SSc . PM/DM . MCTD- . UCTD Clq .. Clq/mRF .. VDR. Clq/mRF.. #1 #2.. 2 . 2) ( 1) . 3.
2 3 .. RA ( ). SLE dsDNA Sm U1 RNP . ( 2-GPI) (aCL) . ( ). (Clq C3d ). 97 . 2003 . C3 C4 . (PPD ). CT( ) ( ) . SSc Scl-70 ( I ) U1 RNP . SS-A SS-B . ( ) KL-6. PM DM Jo-1 U1 RNP SS-A SS-B .. CT( ) . (MCTD) U1 RNP dsDNA Scl-70 . Jo-1 SS-A SS-B . (UCTD) C3 C4 . SLE PSS PM DM RA . ( ) .. [aCL (LA)] . (ANCA) [C(PR-3)-ANCA P(MPO)-ANCA]. dsDNA U1 RNP . (Clq mRF ) . C3 C4 . X ( ) ( ). ( ). SS-A SS-B . ( ).. (aCL LA). CT . 4 ( ).. RA SLE PN . SLE ITP PAIgG aCL LA. (APS). SLE Felty . SLE MCTD. PN AGA PIE.. APS APTT aCL LA . SLE . SSc ( ). ( ) PN (NAG 2-m) ANCA GBM . RA SSc DM CT (DLco ) . (KL-6 SP-D) . Good Pasture GBM ANCA. ( ) ASO A . MCTD SSc . CT .. PN ANCA . ( IgG ) aCL. CNS SLE. CT MRI . X HLA. 3) 4 .. 98 . 22 . 5 .. ( ) . ( ) . ( dsDNA CH50 ) .. 5.
3 #.. 1) pH 1 /1 2 1 / . 2) ( ) 1 / 6 12 . 3) RBC Hb Ht 1 /1 2 1 / . WBC WBC (APTT PT ). 4) AST ALT LD ALP GT UN 1 /1 2 1 / . TG HDL-C Na K . Cl Fe UIBC . 5) RF CH50 ( ) 1 / 3 12 . ( 2) ( ) 1 / 6 12 . (ASO PPD ) ( ) 1 / 12 . 6) ( ) 1 / 12 . #.. 2) : , ( .. ), , 1994. p268 274. 1) : , 3) : ( . ( 2 ). ), , 1994. p275 286. , 1996 ( 15 7 ). 99.
