平成 23 年度報告 毒物劇物指定のための有害性情報の収集・ …

1 23 CAS No. 137-26-8 24 3 1 LD50/LC50 >1000 mg/kg GHS 4 5 2000 mg/kg GHS 5 mg/L/4H GHS 4 GHS 1 EU CLP 1. LD50 LC50 2. CAS No.

2 LD50/LC50 30 Chemical Database (CD) MSDS [ ] International Chemical Safety Cards (ICSC) IPCS , [ 2 ] Fire Protection Guide to Hazardous Materials (NFPA, 13th ed., 2002) NFPA CRC Handbook of Chemistry and Physics (CRC, 85th, 2004) CRC Merck Index (Merck, 14th ed., 2006) Merck and Company, Inc. ChemID US NLM TOXNET 1 [ ] GESTIS IFA [ ] Registry of Toxic Effects of Chemical Substances (RTECS) US NIOSH ( ) MDL Information Systems, Inc.

3 [ , Inc ] Hazardous Substance Data Bank (HSDB) NLM TOXNET [ ] , Inc [RightAnswer ] International Uniform Chemical Information Database (IUCLID) ECB [ ] IUCLID Chemical Data Sheets Information System Patty s Toxicology (Patty, 5th edition, 2001) Wiley-Interscience JECDB OECD GLP [ ] SAX s Dangerous Properties of Industrial Materials (SAX, 11th edition, 2004) Wiley-Interscience Environmental Health Criteria (EHC) IPCS 3[ ] Concise International Chemical Assessment Documents (CICAD) IPCS EHC [ ] EU Risk Assessment Report (EURAR) EU [ ] Screening Information Data Set ( sids ) OECD [ ] ATSDR Toxicological Profile (ATSDR) US ATSDR [ ] ACGIH Documentation of the threshold limit values for chemical substances (ACGIH , 7th edition, 2001)

4 ACGIH MAK Collection for Occupational Health and Safety (MAK) DFG [ ] TOXLINE US NLM [ ] PubMed US NLM [ ] Google Scholar (Google-S) Google [ ] Google Google [ ] ESIS (European chemical Substances Information System) ECB EU CLP[ ] [ ] Recommendation on the Transport of Dangerous Goods, Model Regulations (TDG 16th ed., 2009; 17th ed., 2011) [ ] [ ] 3. 4 sids EHC ACGIH MAK WHO IARC HCN EPA HPV EPA RED SDS CD ( 1) ATSDR ICSC ( 2) CICAD NFPA EURAR CRC ( 3) sids ( 11) Merck ( 4) EHC ( 12) ChemID ( 5) ACGIH ( 13) GESTIS ( 6) MAK ( 14) RTECS ( 7) IARC ( 15) HSDB ( 8) HCN ( 16) IUCLID ( 9)

5 JECDB SAX ( 10) EPA HPV ( 17) Patty EPA RED ( 18) SDS ( 19) TDG ( 20) ESIS ( 21) 2-8, 11, 13, 15 Thiuram, Thiram, Tetramethylthiuram disulfide, Bis (dimethylthiocarbamoyl) disulfide CAS 137-26-8 RTECS JO1400000 UN TDG 3077 ICSC 0757 EC (Annex I Index) 205-286-2 (006-005-00-4) C6H12N2S4 / (CH3)2N-CS-S-S-CS-N(CH3)2 1 g/cm3 (20 C) 129 C ( kPa) 156 C 89 C ( ) 10-5 mmHg (= Pa) (25 C) 1 18 mg/L / (Log P) 1 mL/m3 (1 ppm) = mg/m3 ( g/L) [1 25 C] 1 5-19 ChemID 5 GESTIS 6 RTECS 7 HSDB 8 IUCLID 9 SAX 10 sids 11 EHC 12 ACGIH 13 MAK 14 IARC 15 HCN 16 EPA HPV 17 EPA RED 18 SDS 19 ChemID 5 6 LD50 (LC50) 560 mg/kg 1 1250 mg/kg 2 LDLo 5 g/kg (LD50.)

6 >5000 mg/kg) 3 LDLo 1 g/kg (LD50: >1000 mg/kg) 4 500 mg/m3/4H (= 51 ppm/4H)* 5 *: Pa 25 C 106 x kPa /101 kPa = ppm 51 ppm g/L GESTIS 6 LD50 (LC50) 560 mg/kg 1 400 4000 mg/kg 6 / >1000 or >2000 mg/kg 6 mg/L/4H 5 >102 mg/m3/4H 6 300 1000 mg/m3/4H 6 >6225 mg/m3/4H 7 RTECS 7 LD50 (LC50)

7 560 mg/kg 1, 8 1800 mg/kg 8 1250 mg/kg 2 1350 mg/kg 8 4420 mg/m3/4H 8 500 mg/m3/4H 8 HSDB 8 LD50 (LC50) 560 mg/kg 9 1350 mg/kg 10 >2000 mg/kg 11 7 500 mg/m3/4H 9 IUCLID 9 LD50 (LC50) 1800 mg/kg # 12 560 mg/kg 1 2600 mg/kg # 12 1080 mg/kg # 13 1112 mg/kg ( )

8 , 1278 mg/kg ( ) 14 1350 mg/kg 15 >5000 mg/kg 14,16 >2000 mg/kg #a 12 2000 mg/kg # 17 >7940 mg/kg # 13 mg/L/4H # 18 mg/L/4H 5 > mg/L/4H #b 12 > mg/L/4H 19 > mg/L/4H c 14 # : GLP a : b : ( mg/L) ( mg/L) c : SAX 10 LD50 (LC50) 560 mg/kg 1 1350 mg/kg 15 LDLo 1g/kg (LD50: >1000 mg/kg) 4 500 mg/m3/4H 5 sids 11 LD50 (LC50) 4000 mg/kg 1900 mg/kg 20 4000 mg/kg 3800 mg/kg 20 8 * mg/L/4H *.

9 EHC 12 LD50 (LC50) 865 1300 mg/kg 21 780 865 mg/kg 22 1500 2000 mg/kg 22 >2000 mg/kg 23 ACGIH 13 LD50 (LC50) 620 4000 mg/kg 20,24,25 2300 4000 mg/kg 20,26 >2000 mg/kg 24 300 1000 mg/m3/4H 27 MAK 14 LD50 (LC50) 400 4000 mg/kg 20,24,25 1500 4000 mg/kg 20,26 >2000 mg/kg a 24 >2000 mg/kg 12 3500 11500 mg/m3/4H 18 a.

10 2000 mg/kg 1 IARC 15 LD50 (LC50) 865 mg/kg 25 375 1000 mg/kg 23 1400 5400 mg/kg 20 2300 mg/kg 28 1400 5400 mg/kg 26 9 3300 4500 mg/kg 20 >2000 mg/kg 23 HCN 16 LD50 (LC50) 865 mg/kg 25 640 mg/kg, 620 mg/kg 24 4000 mg/kg, 1900 mg/kg 20 2300 mg/kg 26 4000 mg/kg, 3800 mg/kg 20 >2000 mg/kg 24 300 1000 mg/m3/4H 27 >100 mg/m3/4H 29 EPA HPV 17 LD50 (LC50) 1080 mg/kg