Transcription of 子宮頸癌画像誘導小線源治療と局所再発子宮癌放射線治療 3 …
1 51 2 2012 9 46 1.. 3-D imaging-guided Interstitial-intracavitary Brachytherapy for the Uterine Cervical Carcinoma and Interstitial Brachytherapy for the Recurrenct Uteine Carcinoma . Tadashi SUGITA.. 3 . 3 3 . dose-volume histogram DVH 100 .. 3 .. 1984 . 1 2 . B 10% .. 3 50Gy .. 3 6 10Gy . B . 3 .. 3 .. A . 5 6Gy 1 2 5 1 . 24 .. American Brachytherapy Society .. Key words 3 ..indd 46 12/09/28 10:04. 2 47 . ABS 2000 2 . 3 . -knife . 1999 5 Intensity- National Cancer Institute NCI Modurated Radiation therapy IMRT .. 4 .. 5 . Japanese . Radiation Oncology Study Group JROSG IMRT . 8 2001 . 2003 261 . 73 CDDP20 . 40mg m2 5 36 Carboplatin5 7 1 . 13 Nedaplatine70 80mg m2 15 . 71 . 28 . 244 5 . 100 .. 30 8 . MRI 56mm . 36mm Grade3 . 4 .. B 1 2Gy . 34 12Gy . 46 5 EQD2. P . 6 7 .. Cs-137 .. oxygen enhancement ratio OER .. Cs- .indd 47 12/09/28 10:04.
2 51 2 2012 9 48 3. 137needle Au-198grain Ir-192wire 3 . 1 .. I-197 CT MRI .. Cs-137 .. dose-volume histogram DVH 100.. 10 . 2005 . The Recommendation of the Gynaecological GYN Europian Group of Curietherapie GEC . Europian Society for Therapeutic Radiology and I-125seed Oncology ESTRO Working group . American Brachytherapy Society ABS Image-based 1 Brachytherapy Working Group . the gross tumor volume GTV the high risk clinical target volume HR CTV the intermediate risk CTV IR. Image-guided brachytherapy CTV CTV+1cm D90. IGBT Image-based 100 . intracavitary brachytherapy 90 D100 . ICBT : D100 . IGBT . 3D-image D90 . 3 OAR the organ at risk S . 1970 image-based D2cc . 1990 2cc . IGBT 8 9 3 . =10 . image- S =3 . guided 2Gy EQD2 . CT 3 DVH .. 3D 3D 3D . Kato 8 . A Ra CT 3D 84 . mg Ci 5 . ICRU rectal point dose D2cc D1cc .. IGBT image-based ICBT ICRU.
3 Rectal point dose . CT .. 3 ..indd 48 12/09/28 10:04. 4 49 .. Image-based high-dose-rate 8 . interstitial brachytherapy HDR- HR-CTV D90 OAR D2cc . ISBT : .. Yoshida 18 HDR-ISBT MRI .. IGBT HR-CTV D90 EQD2 . 3 D2cc D2cc 62Gy .. CT MRI . Isohasi 19 . D2cc 72Gy 85Gy . Potter11 12 13 b a Wakatsuki Ohno 20 . MRI 45 1 . 7Gy4 30 . 82 weeklyCDDP40mg m2 . Itami 21 8 9 HDR- ISBT 2 . 2 MRI 1 dose-volume histogram 75% 47 G2 G4 5 . DVH D90 87Gy 100ml . 3 68 87Gy 15 73 .. D90 5cm 3D IGBT . DVH . 141 . LENT SOMA G1G2 9 G3 3 . G1G2 20 G3 1 G4 2 . D2cc 78Gy 10 G2 . DVH D2cc D1cc .. 14 15 . Zelefsky 16 . LENT SOMA 0 D2cc 63Gy . 1 4 D2cc 72Gy .. Saitoh 17 .. CT 102 l 33-174ml . 8 . 7 . 30Gy 20Gy 30Gy . 5 HR-CTV D90 EQD2 . D2cc D2cc . 3 71 . 3 Itami 21 . G3 2 D2cc . 2 G1 2 D2cc 85Gy Charra 22 78 Ir- G3 1 D2cc 192 6 ..indd 49 12/09/28 10:04.
4 51 2 2012 9 50 5.. Paris I-192 .. Cs-137 . 75Gy . 5 70 62 . 8 . G1G2 5 G3 8 . Evance 23 . 114 5 . Puthawala24 40 . 2 67 . 28 . Kotsuma Yosida 25 14 . 3 9 2 7 .. HDR-ISBT54Gy 9 7 30Gy 20Gy HDR-ISBT30Gy 5 . 3 78 . 77 50 2 G2G3 . HDR-ISBT 1 . 3 1 3 . 3 . 3 . Dimopoulos 26 13 . 50Gy HDR-ISBT . 3 92 Cs-137 . 85% 11 13 G1G2 . 2 1 .. 30 HRCTV D90 86Gy D2cc 80Gy 76Gy 70Gy . Image based high-dose-rate 1 . interstitial brachytherapy HDR-ISBT low-dose- 30 496-500 1984. 2 1 . rate interstitial brachytherapy LDR-ISBT :22-27 1987. 3 Monk BJ Tewari KS.:Multimodality therapy for locally advanced cervical carcinoma,State of the art and future directions. JClin Oncol 25 2952 2965, 2007. 4 Concurrent Chemoradiation CCRT . 50 2 :133-139, 2004. 5 Nag S, et al.: the American brachytherapy society recommendations for high-dose-rare brachytherapy for carcinoma of the cervix.
5 J Radiat Oncol Biol Phys 48 :201- 2003 2009 211,2000. 31 17 18 6 Nakano T,et al.: Long-term results of high-dose-rate Cs-137 12 13 intracavitary brachytherapy for squamous cell carcinoma of the 8 uterine cervix. Cancer 103 92 101,2005. 7 Sakata K, et al.: Japan Radiation Oncology Study 2 Group,Results of concomitant chemoradiation for cervical 1 cancer using high dose rate intracavitary brachytherapy,study of 3 JROSG. Acta Onco 47 3 :434-441,2008. 8 Kato S, Tran DN Ohno T, et al.: CT-based 3D dose-volume parameter of the rectum and late rectal complication in patients ..indd 50 12/09/28 10:04. 6 51 . with cervical cancer treated with high-dose-rate intracavitary planning for patients with locally advanced uterine cervical brachytherapy. J Radiat Res 51:215-221, 2010. carcinoma. J Radiat Res 52 4 :490-5,2001. 9 Wakatsuki S, Ohno T, Nakano T: lntracavitary combined 18 Yoshida K, Yamazaki H: A dose-volume analysis of magnetic with CT-guided interstitial brachytherapy for locally advanced resonance imaging-aided high-dose-rate image-based interstitial uterine cervical cancer, lntroduction of the technique and a case brachytherapy for uterine cervical cancer.
6 Int J Radiat Oncol presentation. J Radiat Res 52 1 :54-58, 2011. Biol Phys 77 3 :765-72,2010. 10 Richar Potter, et al.: Recommendations from gynaecological 19 Isohashi F, Yoshioka Y, et al.: Rectal dose and source GYN GEC ESTRO working group II : concepts and strength of the high-dose-rate iridium-192 both affect late rectal terms in 3D image-based treatment planning in cervix cancer bleeding after intracavitary radiation therapy for uterine cervical brachytherapy-3D dose volume parameters and aspects of carcinoma. Int J Radiat Oncol Biol Phys 77 3 :758-64,2010. 3D image-based anatomy, radiation physics, radiobiology. 20 Wakatsuki M, Ohno T, Takahashi T, Nakano T, et al.: Radiother Oncol 78:67-77,2006. Intracavitary combined with CT-guided interstitial brachytherapy 11 P tter R, Dimopoulos J, et al.: 3D conformal HDR-brachy- for locally advanced uterine cervical cancer: introduction of and external beam therapy plus simultaneous cisplatin for high- the technique and a case presentation.
7 J Radiat Res 52 1 :54- risk cervical cancer: clinical experience with 3 year follow-up. 8,2011. Radiother Oncol 79 1 :80-6,2006. 21 Itami J, et al.: Transperineal high-dose-rate interstitial 12 Dimopoulos JC, Lang S,Kirisits C, et al.: Dose-volume radiation therapy in the management of gynecologic histogram parameters and local tumor control in magnetic malignancies. trahlenther Onkol 179 11 :737-41,2003. resonance image-guided cervical cancer brachytherapy. J Radiat 22 Charra C: Outcome of treatment of upper third vaginal Oncol Biol Phys 75:56-63,2009. recurrences of cervical and endometrial carcinomas with 13 Dimopoulos JC,Potter R: Dose-effect relationship for local interstitial brachytherapy. Int J Radiat Oncol Biol Phys 40. control of cervical cancer by magnetic resonance image-guided 2 :421-6,1998. brachytherapy. Radiother Oncol 93 2 :311-5,2009.
8 23 a.: External vsinterstitial irradiation in 14 Georg P, et al.: Correlation of dose-volume parameters, umresectable recurrent cancer of the cervix. Cancer 28:1284- endoscopic and clinical rectal side effects in cervix cancer 1288, 1971. patients treated with definitive radiotherapy including MRI- 24 Puthawala AA, et al.: Re-irradiation with interstitialimplant based brachytherapy. Radiother Oncol 91 2 :173-80,2009. for recurrent pelvic maligmancies. Cancer 50:2810-2814,1982. 15 Georg P, P tter R, et al.: Dose effect relation ship for late side 25 Kotsuma T, Yoshida K,et al.: Preliminary results of effect of the rectum and urinary bladder in magnetic resonance magnetic resonance imaging-aided high-dose-rate interstitial image-guided adaptic cervix cancer brachytherapy. Radiat brachytherapy for recurrent uterine carcinoma after curative Oncol Biol Phys 82 2 :653-7,2012.
9 Surgery. J Radiat 3 :329-34,2001. 16 Zelefsky MJ, Fuks Z,et al.: High-dose intensity modulated 26 Dimopoulos JC, Schmid MP, P tter R, et al.: Treatment of radiation therapy for prostate cancer: early toxicity and locally advanced vaginal cancer with radiochemotherapy and biochemical outcome in 772 patients. Int J Radiat Oncol Biol magnetic resonance image-guided adaptive brachytherapy: Phys 53 5 :1111-6,2002. dose-volume parameters and first clinical results. Int J Radiat 17 Saitoh J, Ohno T, Sakurai H, et al.: High-dose-rate interstitial Oncol Biol Phys 82 5 :1880-8,2012. brachytherapy with computed tomography-based treatment .indd 51 12/09/28 10:04.