Transcription of ハンセン病治療指針（第3版） - hansen-gakkai.jp
1 141 Jpn J Lepr 82, 141-182 2013 *Corresponding author 893-8502 4204 TEL:0994-49-2500 3 *1 2 3 4 5 6 7 8 8 9 3 1 2 3 4 5 6 7 8 9 2013 6 10 2000 2006 WHO MDT 6 WHO/MDT/PB MB A MB BI 3+ WHO/MDT/MB 2 2 1 2 1 3 WHO/MDT/MB + 2 B MB
2 BI 3+ 6 BI 3+ WHO/MDT/MB 1 1 WHO/MDT/MB 1 142 Mycobacterium leprae 1 2 3 4 WHO/MDT 5 6 7 8 9 10 11 12 1 2 3 4 5 6 2000 1 1996 8 4 1 1997 9 3 2 3-8 1 9 6 10 11 1 7 ENL 12 2010 WHO TRS 968 2012 13
3 1 143 Jpn J Lepr 82, 141-182 2013 1 1 WHO 3 WHO 13 WHO 4 1 2 3 M. leprae 4 1 2 3 PCR 1 4 HE, Fite 2 WHO 7 2 LL LL TT BT 1
4 144 pure neural type 15 3 M. leprae Ridley&Jopling 16 WHO MDT, multi-drug therapy 1981 1996 MB multibacillary, PB paucibacil-lary, 2 17-20 1997 SLPB single-lesion paucibacillary, 3 14,21 2010 MB PB 2 13 WHO/MDT WHO/MDT MB PB 4 1 2 1 3 A.
5 M. leprae M. leprae B. M. leprae C. WHO 1 1 2 WHO/MDT 1 1 3 2 MB BI ADL 145 Jpn J Lepr 82.
6 141-182 2013 3 6 M. leprae 1 WHO/MDT MB 4 8 erythema nodosum leprosum: ENL 5 WHO/MDT 1997 12 MB WHO/MDT 4 MB 18 PB 9 DDS
7 1 2 6 7 146 3 1 DDS, dapsone clo-fazimine, CLF, B663 rifampicin, RFP ofloxacin, OFLX 4 M. leprae 22 LVFX SPFX MFLX MINO CAM RBT 1 A. diaphenylsulfone DDS, dapsone 1 75 100mg 1 50 mg 100 mg 4 g/ml 30 23 M.
8 Leprae MIC 3 ng/ml 24 1 1. DDS, 75 100 mg/ CLF, B663 50 mg/ RFP 600 mg/ 1 OFLX 400 mg 500 mg/ 2. LVFX 500 mg/ SPFX 100 200 mg/ MFLX 400 mg/ CAM 400 mg/ MINO 100 mg/ RBT 150 300 mg/ 147 Jpn J Lepr 82, 141-182 2013 25 PABA M. leprae DDS 1 25 mg Lectisol, B.
9 Clofazimine CLF, B663, G30320 1 300 mg 50 mg 1 150 mg 50 mg 200 mg 8 g/ml 26 M. leprae DNA 27 25 erythema nodosum leprosum; ENL 28 ENL 1 1 100 mg ENL 3 ENL 3 DDS, RFP 1 50 mg Lam-pren, C. rifampicin RFP 1 600mg 1 450 mg RFP 600 mg 10 g/ml 29 M.
10 Leprae MIC 300 ng/ml RFP DNA RNA polymerase RNA MDT 1 RFP 1 150 mg Rifadin, D. ofloxacin OFLX 30 1 400 mg 600 mg RFP, MINO 1 400 mg 1 200mg 300 mg g/ml 31 DNA-gyrase DNA 1 100 mg Tarivid, 2 M. leprae E. 1481 levofloxacin LVFX OFLX s- OFLX 2 250 mg 2 500 mg 1 1 LVFX 500 mg 1 1 100 mg 1 3 1 1 500 mg 8 g/ml 32 OFLX 1 250 mg 500 mg Cravit.
