Transcription of 4章 出生前診断（母体血胎児染色体検査（NIPT
1 nipt .. 5 .. 2012 .. 2012 12 . 2013 2013 .. 60 . 46 22 44 2 .. 25 .. 1 . HP .. 38. 21 18 . 13 .. HP .. 21 . 13 18 .. (50 ). (90 ). (10%).. 80 .. 21 .. (50 ). 90 1 50 60 . 50 90 . nipt HP . 39.. nipt .. 40. 2014 .. combined test .. 78(3)146 2014 . 41.. 21 18 .. NT .. nipt 1% 99% .. [ ]. sensitivity .. 15 . 200 300 1 .. 2 3 .. 42.. NT ). ( nipt . /.. 11-13 15-18 10-22 11-15 15 . 21 21 21 .. 18 18 18 . 13 13 . 21 .. 80-85 80-85 .. 1 .. 21 . 15 . 21 80 .. 10 .. 2/3 .. 5 . FISH .. 10,000 20,000 . 210,000 100,000 200,000 . 20,000 30,000 .. nipt HP 2015 . 43. nipt .. 2013 .. Non-Invasive-Prenatal-Testing nipt maternal blood cell-free fetal nucleic acid (cffNA)test . nipt . nipt . nipt . 100 .. nipt .. DNA . DNA nipt . nipt . DNA DNA 10% . 1000 DNA DNA . 21 . 21 DNA DNA 21 .. ( ) . 44.. nipt HP 2015 .. 21 18 13.. 2/3 .. 21 . 13 18 . nipt .
2 nipt .. nipt 21 . 40 . 95% 21 35 84% 30 68% .. nipt 21 . 21 .. 45.. nipt .. nipt .. 13 21 .. 2013 .. 2013,656 . 46. nipt .. 20ml .. 10 22 .. 10 35 . 13 18 21 .. nipt HP 2015 .. 47. 143 , 6 p1169 2014 . 48.. 2012 .. ( . CNS) .. 49.. 21 . 10 22 18 . NZPT 13 . 11 13 .. 21 . 15 18 18 . 13 .. NT .. - AFP). CG . u-E3 . A.. 10 p66 2009 . 50.. 35 .. nipt .. nipt . nipt . 51.. 12 .. 1 . 2 . 3 . 4 . 5 . 6 . 7 . 8 . 9 . 10 . 11 .. 12 . 44 .2 p160. 2014 .. 52.. 53.. 54.. A 40 42 . IVF 10 .. A 40 .. A . A .. 55. 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 .. NT .. nipt .. 143(6) 1142 2014 .. ( ). ( ).. ( ). ( ) .. 56.. / / 2011 2 Q and A . 2014 . WHO Review of Ethical Issues in Medical Genetics 2003 blications/en/ethical_issuesin_me dgenetics% 57.. nipt . nipt 26 10 20 . 48 .. nipt . HP : nipt HP : nipt .. nipt .. 58.. 26 12 . 1.
3 810-8563 1-8-1. TEL 092-852-0700 . 2.. 814-0180 7-45-1. TEL 092-801-1011. URL 2.. 802-8533 10-1. TEL 093-921-8881. URL 4.. 852-8501 1-7-1. 9 -16 TEL 095-819-7548. 5.. 860-8556 1-1-1. TEL 096-373-5669 . URL 6.. 879-5593 . TEL 097-586-6920 13 15 . URL nipt HP 2015 . 59.. 1) 656. 2013,1-3. 2) 656. 2013,6-7. 3) nipt < > 2015 1 5 . 4) .. 24-30, . 38-44. , , .. 2002.. 5) .. , ,2012,111-136. 6) Dale alsey Lea . , . , . 7) .. 8) 2014,44(2)157-161. 9) .. 78(3)2014,146-152. 10) 2 ,MEDIC MEDIA, 2009, 66. 11) . , 143(6)2014, 1166-1170, 12) .. 2014, 143(6),1142. 60.
