42580 Comil Bro - MEDELPHARM

1 ADVANCED SIZE REDUCTION PERFORMANCE&FLEXIBILITYQ uadro Comil Used by global leaders in more than 80countries, the Quadro Comil is theworld s leading technology for achievinguniform size reduction, sieving, deagglomerationdispersionand mixing. In applications throughout thePharmaceutical, Food, Fine Chemical, Personal Care and Cosmetics industries, wherever process managersseek optimum process efficiency and productconsistency that s where the Comil is hard at processing efficiencyQuadro invented the original conical mill in simple in principle, the Comil was arevolutionar yconcept that has since evolved into aglobal processing standard adopted by market leadersaround the world. Today, the Comil s proprietar y,advanced size reduction technology has been refinedthrough thousands of applications to deliver reliablescalability, repeatability and environmentally friendly per formance. The result is superior product quality andmaximum throughput for quick return on and controlOver the past 30 years, the Comil s industr yleadership has been reaffirmed with ever y new productgeneration introduced.

2 Our latest inline designsincorporate a host of innovations that offer greater application versatility along with easier cleaningand performanceWhen you choose the Quadro Comil you can rely onreceiving the superior engineering and manufacturing quality that give you maximum uptime and yield. What s more, ever y Comil isbacked by the highest level of application andtechnicalsupport, based onmore than a quarter centur yof Quadro Comil products Comil The Industry Standard for Over a19761977198419901996 Model 196 FirstComil broughtto marketModel 197 Small productionmodel introducedModel 194 Mid-size productionmodel introducedModel U20 Comil underdrivenline establishedSeries 2000 Comil global designRevolutionary technology that has stood the test of timeTHE QUADRO Comil HERITAGEM odel U3 First Scalable R&D/Lab Model IntroducedModel F10 Fine Grind Series, micron millingTheQuadro Comil comesin 35 standard models, available withover 200 screen types anddozens of different impellers the industr y s most extensive lineof conical milling Century200120032005 Model U5 Pilot & DevelopmentScale MillDYNAMIC PRINCIPLES1.

3 In the conical screen chamber, a rotatingimpeller imparts a vortex flow pattern to theinfeed The product is forced outward to the screensur face by centrifugal acceleration, ensuringcontinuous deliver y into the "action zone"between the screen and In the "action zone" the material is uniformlysized and instantaneously passed tangentiallythrough the screen The finished product is discharged at the bottom of the milling OverdrivenQuality engineered forreliable, low-maintenanceoperation, the Comil strack record for high-efficiency inlineprocessing is unequaled across a vastrange of applications from sizereduction to mixing and dispersion,bulk density adjustment to separationand performanceTheComil Overdriven is available in five models, offering capacities up to 120,000 lb/hr (54,500 kg/hr).Specialized per formance options arealso in stainless steel for sanitar y operation and easy cleanability,theComil Overdriven can be flood fed(control feeding is not necessar y).

4 Milling action can be fine tuned using a comprehensive selection ofinterchangeable tooling, as well as speed heat, low noise, low dustThe original Comil s innovative,low-speed design applies an inherentlygentle action to the product, achievingoptimum particle granulometr ywhilegenerating limited or no heat, low noise and minimal fines. In addition tolow energy consumption, the result is a consistent, high-quality end product,even with heat-sensitive overdriven models (no belts) are available for capacities up tolarge production sizes.(1)Capacities are based on standard pharmaceutical placebo with 3% cr ystalline cellulose (CMC). (2)Capacities may var y significantly based on product characteristics, particle granulometr y, inlet and discharge conditions. Consult your local representative or Quadro for product testing. (3)For some products, capacities reach the following higher limits: (a)15,000 lb/h (6,800 kg/h), (b)35,000 lb/h(15,900 kg/h), (c)60,000 lb/h (27,000 kg/h), (d)120,000 lb/h (54,500 kg/h).

5 SPECIFICATIONSPROVENSIZEREDUCTIONTECHNOL OGYDELUMPINGDOWNTO<500 MICRONS"When we replaced our oscillating granulator with aComil for delumping sodium and potassiumchlorides, the results were impressive. Dust levelswere minimized, and equally if not more important,processing time was reduced by 50%."Norgine Ltd., South Wales, achieve the tight particle size range required to produce their "Movicol" product, Norgine hadbeen delumping chlorides in small batches usingan oscillating granulator. The Comil per formed sowell, that they purchased a second unit for sizingdried granules for their "Camcolit" and "Destolit" OFOPERATIONSOLUTION PROFILES odium and potassium chlorides are dried ontrays, then tipped into the inlet of the Comil through a specially designed feed hopper,reducing dust levels to an absolute Model 197 S with standard feed chute can be customizedto meet all process feed requirements (manual,pneumatic or mechanical). housing with super-sanitar y spindle assembly.

6 Canalso be modified for clean-in-place (CIP) discharge shroudallows quick changeover ofscreens, impellers, customizedtooling for special allows for easy be custom engineered to fitany process or collection machine available invarious grades of stainless steeland specialty guard compact for easyremoval, gasketted for addedprotection of drive components.(See inset for illustration ofdirect driven model.) features to meet all international safety guidelinesand steel motor shield forsanitar y UnderdrivenBased on the samerevolutionar y technology as our overdriven model,theComil Underdriven provides all the features and options of theoriginalComil with additionaladvantages, including easier inline design, increasedthroughputThis mill s advanced, compact designand extremely short head heightprovide for easy integration into processing environments where headroom is limited. A large-diameterinfeed and straight through housing(with no offset between inlet and outlet) promote unhindered inlineproduct flow for quicker in four models, the Comil Underdriven is scalable in capacityfrom several ounces (grams) to35,000 lb/hr (15,900 kg/hr).

7 Innovative "quick change"toolingFine tuning the mill for optimumgranulometr y is simplified by means of an innovative spacerless design,which allows for quick changeover ofimpellers and screens. Specializedtooling is available to meet allprocess requirements. A variable-speedfeature provides for even greatercontrol of process per gm or 3 oz (1)Capacities are based on standard pharmaceutical placebo with 3% cr ystalline cellulose (CMC). (2)Capacities may var y accordingly based on product characteristics, particle granulometr y, inlet anddischarge conditions. Consult your local representative or Quadro for product testing. (3)For some products, capacities reach the following higher limits: (a)15,000 lb/h (6,800 kg/h),(b)35,000 lb/h (15,900 kg/h).(4)U3 model is generally designed for lab and research IN short housing heightfor installation in productionenvironments where space infeed diameter for upto 50% higher capacity thanconventional design providesoptimum impeller/screengap for superior particlegranulometr y and per sur face area resulting in maximum productflow and lower cleaning , sanitar y designincludes all sanitar y connections and ultra-sanitar ygearbox.

8 Fully automatic CIP capability changeover of screensand impellers, no specialtools Inlet and outlet can be customized to fit anyprocess Safety features to meetall international guidelines and Underdriven s cGMPdesign and minimum sur facearea of contact make it easyto clean, as well as offering quick disassembly andassembly for "Not only did the Quadro Comil meet our moststringent requirements for use in hazardouslocations, the portable design of the systemallowed for remarkable flexibility, along with easyoperation and cleaning."Pfizer Inc., Michigan, Pfizer required a portable inert mill for usethroughout their new, state-of-the-art researchfacility in Michigan, they turned to Quadro. We engineered a custom solution that included an air-purge electrical panel, inert gas inlet andoutlet ports, a closed-loop oxygen control system,and infeed chutes for both inline and hand to starting, the Comil is purged with N2inorder to produce inert operating conditions.

9 Duringmilling, should the oxygen level rise to the presetmaximum, the N2purge is activatedautomatically to halt the rise. Shouldthis continue, an alarm will sound andtheComil will shut Model U10 METHOD OFOPERATIONSAFE, VERSATILEINERTMILLINGSOLUTION PROFILEDRY MILLINGSIZE REDUCTIONDr y granulation in tablet manufacturing. Dr ysolubles. High-throughput bulk density fine dr y granules. Sizing compacted MILLINGSIZE REDUCTIONSize reduction and milling of wet or soaked products to produce liquid with wet suspended particulate. Powders into pastes. Wet sizing of wet granulation in tablet MIXINGDISPERSIONI deal for a broad range of dr y mixing, finishingand dispersion tasks. Lump-free homogeneousblending to precise size requirements. Low heatbuildup and precise screen size ensure completedispersion at desired particle difficult, sticky, heat-sensitive agglomerates into pieces, crumbs or powders ofuniform size, continuously without excessive heatbuildup or screen blockage.

10 Preser ves quality offragile products. Replaces labor intensive, expensive manual breaking action enables the Comil topowderize heat-sensitive products such asshortening and cream filled products. Hard,compacted products can also be size reducedwith minimal Expertise Gained Through More Than 20,000 ApplicationsFor more than 30 years,Quadro hasbeen continuallyrefining and improvingComil technology. During this time,we have partnered with our customers,successfully developing thousands ofcustom applications to provideincreased productivity, versatility and problem solvingUnparalleled experience enables us to offer a level of application problem-solving expertise second to none whether you re reclaimingpharmaceutical powders from gelatincapsules, per forming closed-loop inertmilling, granulating freeze-dried foodproducts with minimum retention timeor delumping wet, sticky knowledgeIn designing for your application,Quadro engineers draw on one of the most comprehensive databases ofprocessing knowledge.