Transcription of 易安穩穩穩穩 5/80 衛署藥輸字第 024824 10/160 衛 …
1 5/80 024824 10/160 024823 Exforge Film coated tablets 5/80mg 10/160mg Exforge (amlodipine valsartan) / Exforge (amlodipine valsartan) amlodipine valsartan [ ] 5/80mg NVR NV 10/160mg NVR UIC Exforge amlodipine besylate dihydropyridine (CCB) Amlodipine besylate Amlodipine besylate 3 5 (4RS) 2 [(2 ) ] 4 (2 ) 6 1,4 3,5 C20H25 ClN2O54C6H6O3S Valsartan II AT1 Valsartan Valsartan (1 ) [[2 (1 5 ) [1,1 ] 4 ] ] C24H29N5O3 Exforge amlodipine besylate ( 5 mg 10 mg amlodipine )
2 80 mg 160 mg valsartan 2 5/80 mg 10/160 mg 5/320 mg 10/320 mg Amlodipine Amlodipine amlodipine Amlodipine (negative inotropic effect) amlodipine amlodipine (pKa= ) Amlodipine Valsartan II (ACE II) I II Valsartan II ( ) AT1 II II AT2 AT2 AT2 Valsartan AT1 ( 20,000 ) valsartan AT1 AT2 valsartan AT1 valsartan 200 1 I II valsartan ( II) Valsartan II II II valsartan Amlodipine amlodipine 6 12 amlodipine 64% 90% Amlodipine Amlodipine 21 L 93% amlodipine Amlodipine ( 90%)
3 10% 60% Amlodipine 30 50 amlodipine 7 8 amlodipine Valsartan valsartan 2 4 valsartan 25% ( 10% 35%) valsartan ( ) 40% (Cmax) 50% valsartan 17 L valsartan Valsartan (95%) Valsartan 6 20% Valeryl 4 hydroxy Valsartan 9% valsartan CYP 450 Valsartan ( 83% ) ( 13% ) valsartan 2 L/h L/h ( 30%) Exforge Exforge valsartan amlodipine 3 6 8 Exforge valsartan amlodipine Amlodipine amlodipine 40% 60% amlodipine Valsartan valsartan ( ) 70% 35% Valsartan Valsartan Amlodipine Amlodipine Valsartan ( ) valsartan ( ) ( < 10 mL/min) Valsartan valsartan Amlodipine amlodipine 40% 60% amlodipine Valsartan valsartan ( )
4 2 ( ) Amlodipine amlodipine amlodipine amlodipine 24 Amlodipine ( 105 114 mmHg) ( 90 104 mmHg) 50% (+1/ 2 mmHg) amlodipine amlodipine ( ) dP/dt amlodipine Amlodipine 10 mg A H H V amlodipine amlodipine amlodipine Amlodipine Norvasc Valsartan Valsartan II 80 mg 80% 30% 24 II 2 3 II valsartan valsartan valsartan Valsartan Diovan Exforge
5 Exforge (amlodipine valsartan) Amlodipine valsartan II Exforge 2 2 Exforge 1,018 amlodipine valsartan (5/80 5/160 5/320 mg) amlodipine (5 mg) valsartan (80 160 320 mg) 8 Exforge Valsartan Amlodipine 0 mg 80 mg 160 mg 320 mg * * * * 0 mg 5 mg * 8 (mmHg) mmHg Exforge Valsartan Amlodipine 0 mg 80 mg 160 mg 320 mg * * * * 0 mg 5 mg * 8 (mmHg) mmHg 1250 amlodipine valsartan ( 10/160 10/320 mg) amlodipine (10 mg) valsartan (160 320 mg) 8 Exforge Valsartan Amlodipine 0 mg 160 mg 320 mg * * * 0 mg 10 mg * 8 (mmHg)
6 MmHg Exforge Valsartan Amlodipine 0 mg 160 mg 320 mg * * * 0 mg 10 mg * 8 (mmHg) mmHg 947 valsartan 160 mg amlodipine valsartan ( 10/160 5/160 mg) valsartan (160 mg) 8 Exforge / * ** * ** Exforge 10/160 mg Exforge 5/160 mg Valsartan 160 mg * 8 / ( / ) mmHg ** = Exforge (Valsartan 160 mg) 944 valsartan 10 mg amlodipine valsartan ( 10/160 mg) amlodipine (10 mg) 8 Exforge / * ** * ** Exforge 10/160 mg Valsartan 10 mg * 8 / ( / ) mmHg ** = Exforge (Amlodipine 10 mg) 6 130 ( 171/113 mmHg) Exforge Exforge / ( 19 92 ) ( ) Exforge Exforge 4% Exforge (amlodipine valsartan) ( ) ( ) Exforge (amlodipine valsartan)
7 / valsartan valsartan ( ) ( ) valsartan (CST) (NST) (BPP) II / Exforge (amlodipine valsartan) ( / ) Exforge valsartan valsartan valsartan Valsartan (VALIANT)
8 Valsartan captopril valsartan captopril amlodipine amlodipine Exforge / / Amlodipine Amlodipine (t ) 56 amlodipine Valsartan valsartan valsartan ( ) valsartan 4 12 valsartan valsartan (susceptible individual) / ( ) / valsartan Amlodipine 1,153 NYHA III IV digoxin Amlodipine ( 5 10 mg) 6 14 ( ) 4 8 12 697 NYHA II/III Amlodipine NYHA (LVEF)
9 Valsartan valsartan / / valsartan Valsartan 93% (valsartan ) Valsartan (VALIANT) valsartan captopril Amlodipine Exforge 50% valsartan 50% valsartan captopril Exforge ( 150%) Exforge 20% valsartan 10% 20% (BUN) Exforge 50% valsartan 50% amlodipine valsartan ( ) Exforge Amlodipine amlodipine thiazide digoxin warfarin Cimetidine amlodipi
