Transcription of 易安穩穩穩穩 5/80 衛署藥輸字第 024824 10/160 衛 …
1 5/80 024824 10/160 024823 exforge Film coated tablets 5/80mg 10/160mg exforge (amlodipine valsartan) / exforge (amlodipine valsartan) amlodipine valsartan [ ] 5/80mg NVR NV 10/160mg NVR UIC exforge amlodipine besylate dihydropyridine (CCB) Amlodipine besylate Amlodipine besylate 3 5 (4RS) 2 [(2 ) ] 4 (2 ) 6 1,4 3,5 C20H25 ClN2O54C6H6O3S Valsartan II AT1 Valsartan Valsartan (1 ) [[2 (1 5 ) [1,1 ] 4 ] ] C24H29N5O3 exforge amlodipine besylate ( 5 mg 10 mg amlodipine ) 80 mg 160 mg valsartan 2 5/80 mg 10/160 mg 5/320 mg 10/320 mg Amlodipine Amlodipine amlodipine Amlodipine (negative inotropic effect) amlodipine amlodipine (pKa= )
2 Amlodipine Valsartan II (ACE II) I II Valsartan II ( ) AT1 II II AT2 AT2 AT2 Valsartan AT1 ( 20,000 ) valsartan AT1 AT2 valsartan AT1 valsartan 200 1 I II valsartan ( II) Valsartan II II II valsartan Amlodipine amlodipine 6 12 amlodipine 64% 90% Amlodipine Amlodipine 21 L 93% amlodipine Amlodipine ( 90%) 10% 60% Amlodipine 30 50 amlodipine 7 8 amlodipine Valsartan valsartan 2 4 valsartan 25% ( 10% 35%) valsartan ( ) 40% (Cmax) 50% valsartan 17 L valsartan Valsartan (95%) Valsartan 6 20% Valeryl 4 hydroxy Valsartan 9% valsartan CYP 450 Valsartan ( 83% )
3 ( 13% ) valsartan 2 L/h L/h ( 30%) exforge exforge valsartan amlodipine 3 6 8 exforge valsartan amlodipine Amlodipine amlodipine 40% 60% amlodipine Valsartan valsartan ( ) 70% 35% Valsartan Valsartan Amlodipine Amlodipine Valsartan ( ) valsartan ( ) ( < 10 mL/min) Valsartan valsartan Amlodipine amlodipine 40% 60% amlodipine Valsartan valsartan ( ) 2 ( ) Amlodipine amlodipine amlodipine amlodipine 24 Amlodipine ( 105 114 mmHg) ( 90 104 mmHg) 50% (+1/ 2 mmHg) amlodipine amlodipine ( )
4 DP/dt amlodipine Amlodipine 10 mg A H H V amlodipine amlodipine amlodipine Amlodipine Norvasc Valsartan Valsartan II 80 mg 80% 30% 24 II 2 3 II valsartan valsartan valsartan Valsartan Diovan exforge exforge (amlodipine valsartan) Amlodipine valsartan II exforge 2 2 exforge 1,018 amlodipine valsartan (5/80 5/160 5/320 mg) amlodipine (5 mg) valsartan (80 160 320 mg) 8 exforge Valsartan Amlodipine 0 mg 80 mg 160 mg 320 mg * * * * 0 mg 5 mg * 8 (mmHg) mmHg exforge Valsartan Amlodipine 0 mg 80 mg 160 mg 320 mg * * * * 0 mg 5 mg * 8 (mmHg)
5 MmHg 1250 amlodipine valsartan ( 10/160 10/320 mg) amlodipine (10 mg) valsartan (160 320 mg) 8 exforge Valsartan Amlodipine 0 mg 160 mg 320 mg * * * 0 mg 10 mg * 8 (mmHg) mmHg exforge Valsartan Amlodipine 0 mg 160 mg 320 mg * * * 0 mg 10 mg * 8 (mmHg) mmHg 947 valsartan 160 mg amlodipine valsartan ( 10/160 5/160 mg) valsartan (160 mg) 8 exforge / * ** * ** exforge 10/160 mg exforge 5/160 mg Valsartan 160 mg * 8 / ( / ) mmHg ** = exforge (Valsartan 160 mg) 944 valsartan 10 mg amlodipine valsartan ( 10/160 mg) amlodipine (10 mg) 8 exforge / * ** * ** exforge 10/160 mg Valsartan 10 mg * 8 / ( / ) mmHg ** = exforge (Amlodipine 10 mg) 6 130 ( 171/113 mmHg) exforge exforge / ( 19 92 ) ( )
6 exforge exforge 4% exforge (amlodipine valsartan) ( ) ( ) exforge (amlodipine valsartan) / valsartan valsartan ( ) ( ) valsartan (CST) (NST) (BPP) II / exforge (amlodipine valsartan) ( / ) exforge valsartan valsartan valsartan Valsartan (VALIANT)
7 Valsartan captopril valsartan captopril amlodipine amlodipine exforge / / Amlodipine Amlodipine (t ) 56 amlodipine Valsartan valsartan valsartan ( ) valsartan 4 12 valsartan valsartan (susceptible individual) / ( ) / valsartan Amlodipine 1,153 NYHA III IV digoxin Amlodipine ( 5 10 mg) 6 14 ( ) 4 8 12 697 NYHA II/III Amlodipine NYHA (LVEF)
8 Valsartan valsartan / / valsartan Valsartan 93% (valsartan ) Valsartan (VALIANT) valsartan captopril Amlodipine exforge 50% valsartan 50% valsartan captopril exforge ( 150%) exforge 20% valsartan 10% 20% (BUN) exforge 50% valsartan 50% amlodipine valsartan ( ) exforge Amlodipine amlodipine thiazide digoxin warfarin Cimetidine amlodipine cimetidine amlodipine 20 240 mL 10 mg amlodipine amlodipine Maalox ( ) Maalox amlodipine amlodipine Sildenafil 100 mg sildenafil (Viagra )
9 Amlodipine amlodipine sildenafil Atorvastatin 10 mg amlodipine 80 mg atorvastatin atorvastatin Digoxin amlodipine digoxin digoxin Warfarin amlodipine warfarin warfarin Valsartan valsartan amlodipine atenolol cimetidine digoxin furosemide glyburide hydrochlorothiazide indomethacin valsartan atenolol atenolol Warfarin valsartan warfarin valsartan warfarin CYP 450 valsartan CYP 450 valsartan CYP 450 II ( spironolactone triamterene amiloride) / Amlodipine
