Transcription of 易安穩穩穩穩 5/80 衛署藥輸字第 024824 10/160 衛 …
1 5/80 024824 10/160 024823 Exforge Film coated tablets 5/80mg 10/160mg Exforge (amlodipine valsartan) / Exforge (amlodipine valsartan) amlodipine valsartan [ ] 5/80mg NVR NV 10/160mg NVR UIC Exforge amlodipine besylate dihydropyridine (CCB) Amlodipine besylate Amlodipine besylate 3 5 (4RS) 2 [(2 ) ] 4 (2 )
2 6 1,4 3,5 C20H25 ClN2O54C6H6O3S Valsartan II AT1 Valsartan Valsartan (1 ) [[2 (1 5 ) [1,1 ] 4 ] ] C24H29N5O3 Exforge amlodipine besylate ( 5 mg 10 mg amlodipine ) 80 mg 160 mg valsartan 2 5/80 mg 10/160 mg 5/320 mg 10/320 mg Amlodipine Amlodipine amlodipine Amlodipine (negative inotropic effect) amlodipine amlodipine (pKa= )
3 Amlodipine Valsartan II (ACE II) I II Valsartan II ( ) AT1 II II AT2 AT2 AT2 Valsartan AT1 ( 20,000 ) valsartan AT1 AT2 valsartan AT1 valsartan 200 1 I II valsartan ( II)
4 Valsartan II II II valsartan Amlodipine amlodipine 6 12 amlodipine 64% 90% Amlodipine Amlodipine 21 L 93% amlodipine Amlodipine ( 90%) 10% 60% Amlodipine 30 50 amlodipine 7 8 amlodipine Valsartan valsartan 2 4 valsartan 25% ( 10% 35%) valsartan ( ) 40% (Cmax) 50% valsartan 17 L valsartan Valsartan (95%) Valsartan 6 20% Valeryl 4 hydroxy Valsartan 9% valsartan CYP 450 Valsartan ( 83% ) ( 13% ) valsartan 2 L/h L/h ( 30%)
5 Exforge Exforge valsartan amlodipine 3 6 8 Exforge valsartan amlodipine Amlodipine amlodipine 40% 60% amlodipine Valsartan valsartan ( ) 70% 35% Valsartan Valsartan Amlodipine Amlodipine Valsartan ( ) valsartan ( ) ( < 10 mL/min) Valsartan valsartan Amlodipine amlodipine 40% 60% amlodipine Valsartan valsartan ( ) 2 ( )
6 Amlodipine amlodipine amlodipine amlodipine 24 Amlodipine ( 105 114 mmHg) ( 90 104 mmHg) 50% (+1/ 2 mmHg) amlodipine amlodipine ( ) dP/dt amlodipine Amlodipine 10 mg A H H V amlodipine amlodipine amlodipine Amlodipine Norvasc Valsartan Valsartan II 80 mg 80% 30% 24 II 2 3
7 II valsartan valsartan valsartan Valsartan Diovan Exforge Exforge (amlodipine valsartan) Amlodipine valsartan II Exforge 2 2 Exforge 1,018 amlodipine valsartan (5/80 5/160 5/320 mg) amlodipine (5 mg) valsartan (80 160 320 mg) 8 Exforge Valsartan Amlodipine 0 mg 80 mg 160 mg 320 mg * * * * 0 mg 5 mg * 8 (mmHg)
8 MmHg Exforge Valsartan Amlodipine 0 mg 80 mg 160 mg 320 mg * * * * 0 mg 5 mg * 8 (mmHg) mmHg 1250 amlodipine valsartan ( 10/160 10/320 mg) amlodipine (10 mg) valsartan (160 320 mg) 8 Exforge Valsartan Amlodipine 0 mg 160 mg 320 mg * * * 0 mg 10 mg * 8 (mmHg) mmHg Exforge Valsartan Amlodipine 0 mg 160 mg 320 mg * * * 0 mg 10 mg * 8 (mmHg)
9 MmHg 947 valsartan 160 mg amlodipine valsartan ( 10/160 5/160 mg) valsartan (160 mg) 8 Exforge / * ** * ** Exforge 10/160 mg Exforge 5/160 mg Valsartan 160 mg * 8 / ( / ) mmHg ** = Exforge (Valsartan 160 mg) 944 valsartan 10 mg amlodipine valsartan ( 10/160 mg) amlodipine (10 mg) 8 Exforge / * ** * ** Exforge 10/160 mg Valsartan 10 mg * 8 / ( / ) mmHg ** = Exforge (Amlodipine 10 mg) 6 130 ( 171/113 mmHg) Exforge Exforge / ( 19 92 ) ( ) Exforge Exforge 4% Exforge (amlodipine valsartan)
10 ( ) ( ) Exforge (amlodipine valsartan) / valsartan valsartan
