（検8）05資料4 門脇構成員 随時血糖値の判定基準について …

1 28 11 8 . 4. 8 .. 1.. 2. (1). 100mg/dL, HbA1c 100mg/dL . 109mg/dL . ( 1: .. , 51 281, 2008).. 100mg/dL HbA1c . HbA1c HbA1c . 100mg/dL 100mg/dL . HbA1c . HbA1c .. ( 2: . 19 2 *HbA1c NGSP ). 3. (2). 126mg/dL, HbA1c . 126mg/dL 75g 2 200mg/dL . 200mg/dL . HbA1c 4. ( 3: 55:485, 2012).. Q1. 100mg/dL(= . ) HbA1c .. Q2. 126mg/dL . HbA1c (= ) .. 5. /75gOGTT2 . 450 . 126mg/dL 200mg/dL. 100mg/dL 140mg/dL. ( 4: .. 6. ROC . 12 243, 1989). 100gOGTT2 . 120mg/dL . 100gOGTT2 160mg/dL 75gOGTT2 140mg/dL , 100gOGTT2 240mg/dL 75gOGTT2 200mg/dL , . ( 7: : 75g GTT 100g GTT . 25: 28, 1982). ( 5: .. 24, 2010). ( 6: . , 7. 41 (Suppl. 2) A101, 1998). 75gOGTT2 . 491 .. ( 8: . 75gOGTT 2 10 .. 51:257,1999) 8.. 75gOGTT2 . ( ) . ( ) ( ) .. 100mg/dL . 126mg/dL 75gOGTT2 . 200mg/dL .. 9. Q1. 100mg/dL .. 1.. 2.. 10.. ( 9: . Screening . 31:117,1988) 11.. 100mg/dL . ( , ) . 100mg/dL SD ,SD . SD, + SD. 100mg/dL . (SD) .. 100 100. ~ 141 137. ~ 125 121.

2 ~ 111 108. ~ 104 101. ( 9: . Screening . 31:117,1988) 12. 24 . 14 15 . ( ).. BMI 23 (n=14). BMI 37 (n=15). ( 10: K S Polonsky et al. Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. J Clin Invest. 81 442,1988). 3 3 . 140mg/dL . 3 13. 75gOGTT2 . 491 .. OGTT .. ( 8: . 75gOGTT 2 10 .. 51:257,1999) 14. 24 . OGTT 24 ( 16 , 8 ). minimed Gold (Medtronic, Inc) . Continuous Glucose Monitoring CGM . 75gOGTT 24 . 4 . CGM CGM . 100mg/dL OGTT 120mg/dL 140mg/dL 4 100mg/dL . *CGM . * 89mg/dL . ( 11: . Daily Glucose Profiles in Japanese People with Normal Glucose Tolerance as 15. Assessed by Continuous Glucose Monitoring. DIABETES TECHNOLOGY & THERAPEUTICS 11:457, 2009 ). 24 . CGM .. ( ~ ) ( ~ ). ( ~ ) ( ~ ). ( ~ ) ( ~ ). 1 .. ( 11: . Daily Glucose Profiles in Japanese People with Normal Glucose Tolerance as Assessed by Continuous Glucose Monitoring. DIABETES TECHNOLOGY & THERAPEUTICS 11:457, 2009 ) 16.

3 Q1. 100mg/dL .. 1.. 2.. A1.. 100mg/dL . 1 140mg/dL . 3 4 , 100mg/dL . 17. Q2. 126mg/dL(= ).. -1. , 200mg/dL . , . 200mg/dL . 126mg/dL . 200mg/dL . (1982 ). (1) , , . 200mg/dL , . (2) , . 75g GTT , . (3) ( ) , . ( 25: 859-866, 1982) 18. Q2. 126mg/dL(= ).. -2. 1.. 2.. 19. 75gOGTT2 . 491 .. OGTT . 1 . 180mg/dL .. (120mg/dL) . ( 8: . 75gOGTT 2 10 . 51:257,1999) 20. 75gOGTT . 450 . OGTT .. 170mg/dL 90% . ( 4: .. 21. ROC . 12 243, 1989).. OGTT 53 53 2 56 . minimed Gold (Medtronic, Inc) . Continuous Glucose Monitoring CGM . ( ). 2 . 180mg/dL. 180mg/dL . ( 12: Chun Wang et al. Glucose fluctuations in subjects with normal glucose tolerance, impaired glucose 22. regulation and newly diagnosed type 2 diabetes mellitus. Clinical Endocrinology 76:810, 2012).. 2 . 97 13 102 17 146 46. 98 15 103 21 145 58. 98 14 103 147 145 57. 34 19 43 31 75 38.. 131, 112 150 155, 124 186 221, 183 259. ( 1SD . 46 24 50 32 73 33.. 144, 120 168 153, 121 185 218, 185 251.)

4 ( 1SD . 43 24 42 26 70 36.. 140, 116 164 145, 119 171 215, 179 251. ( 1SD . 180mg/dL .. ( 12: Chun Wang et al. Glucose fluctuations in subjects with normal glucose tolerance, impaired glucose 23. regulation and newly diagnosed type 2 diabetes mellitus. Clinical Endocrinology 76:810, 2012). Q2. 126mg/dL(= ) .. -2. 1.. 2.. A2. 180mg/dL .. 24.. 75gOGTT2 . ( ) ( ) ( ) .. 100mg/dL. 1 140mg/dL . 3 4 , 100mg/dL . , 200mg/dL .. 126mg/dL . 75gOGTT2 200mg/dL . 180mg/dL 25.. HbA1c . HbA1c .. [ ]. 4 . 100mg/dL .. HbA1c . [ ]. 1 200mg/dL .. 2 180mg/dL .. 26.))