9 789860 309171 - nhri.org.tw

1 9 789860309 1719 789860309 171 (CIP) / TCOG .. , ISBN 978-986-03-0917-1 ( ) 1. 2. 100026708 ( nhri ) (TCOG) TCOG 35053 35 886-37-246166 2011 12 150 209 1 886-2-2518-0207 886-2-2518-0778 6 886-4-2226-0330 886-4-2225-8234 GPN 1010004539 ISBN 978-986-03-0917-1 [ ] 2011 12 TCOG.

2 1 .. 2 .. 7 .. 10 .. 16 .. 22 .. 68 .. 74 .. 80 .. 97 .. 116 .. 122 .. 125 .. 126 1 (TCOG) 1998 2010 TCOG 2 ( ) ( ) ( ) 3 (90% ) 1.

3 (1) [1] (2) (3) (4) (5) 2. 45 (1) (2) ( ) TCOG 4 (3) (4) (5) (6) (7) (8) (9) (10) (11) 2008 4 (2010 12 ) [2] 6 40-70 5 1995-2008 1979-2008 1979 198519901995 200020052008 19980 2 4 6 8 10 12 14 16 18 1995 1996 19971999 2000 2001 2002 2003 2004 2005 2006 2007 2008 TCOG 6 97 88 97 88 ( 88 97 )

4 [1] Tsai KY, Su CC, Lin YY, Chung JA, Lian IeB. Quantification of betel quid chewing and cigarette smoking in oral cancer patients. Com-munity Dent Oral Epidemiol 2009; 37(6):555-61. [2] Cancer registry annual report, 2008 Taiwan. Available from: http:// Accessed MAY 19, 2011. 7 (T) (N) (M) TNM (UICC AJCC 2010 ) [1] ( ) TNM (T) Tx T0 Tis (carcinoma in situ) T1 2 T2 2 4 T3 4 T4 T4a ( ) ( [ ] ) TCOG 8 (T) T4b T4 (N) Nx N0 N1 3 N2a 3 6 N2b 6 N2c 6 N3 6 (M)

5 M0 M1 T N M 9 T N M 0 Tis N0 M0 I T1 N0 M0 II T2 N0 M0 III T3 / T1-3 N0 / N1 M0 IVa T4a / T1-3 N0-2 / N2 M0 IVb Any T / T4b N3 / any N M0 IVc Any T Any N M1 [1] Greene FL, Page DL, Fleming ID, Fritz AG, Balch CM. editors. AJCC Cancer Staging Manual. 7th ed. New York: Springer-Verlag; 2010. TCOG 10 ( ) 1. (1) (comorbidity factor) [1-2] 11 [3] (2) [4] [1] (3) X (bone scan) ([18F] fluorodeoxyglucose (FDG) positron emission tomography (PET) scan)

6 SUVmax TCOG 12 [5] A. (mandible) (maxilla) X X X 50% [6] (panoramic view) [1] B. [7] (cortical bone) 13 (4) (synchronous malignancy) (upper aerodigestive tract) (field cancerization) [8] (synchronous) (metachronous) (synchronous esophagus neoplasia, including esophageal cancer and precancer lesions of esophagus) [9] (metachronous esophageal cancer) 2% [10] (5) (alcohol withdrawal syndrome) [1,11] 2.

7 TCOG 14 [1] Shah JP, et al. Oral Cancer. 1st edition. United Kindom (UK): Martin Duntiz; 2003. [2] Singh B, et al. Validation of the Charlson comorbidity index in pa-tient with head and neck cancer: a multi-institutional study. Laryn-goscope 1997; 107:1469-75. [3] Ondrey FG, et al. Effects of nutrition on wound healing. Otolaryngol Head Neck Surg 1994; 110:557-9. [4] Maier H, et al. Dental status and oral hygiene in patients with head and neck cancer. Otolaryngol Head Neck Surg 1993; 108:655-61. [5] Liao CT, et al. Preoperative [18F]fluorodeoxyglucose positron emis-sion tomography standardized uptake value of neck lymph nodes predicts neck cancer control and survival rates in patients with oral cavity squamous cell carcinoma and pathologically positive lymph nodes.

8 Int J Radiat Oncol Biol Phys 2009; 74:1054-61. [6] Weisman RA, et al. Bone scanning in assessment of mandibular invasion by oral cavity carcinomas. Laryngoscope 1982; 92:1-4. [7] Iwai H, et al. Magnetic resonance determination of tumor thickness as predictive factor of cervical metastasis in oral tongue carcinoma. Laryngoscope 2002; 112:457-61. [8] Slaughter DP, et al. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 1953; 15 6:963-8. [9] Wang WL, et al. Risk Factors for Developing Synchronous Esopha-gus Neoplasia in Patients with Head and Neck Cancer. Head Neck 2011; 33:77-81. [10] Su YY, et al. Detection of Metachronous Esophageal Squamous Carcinoma in Patients with Head and Neck Cancer Using Trans-nasal Esophagoscopy. Head Neck 2010; 32:780-5. [11] Kuo YR, et al. Microsurgical tissue transfers for head and neck reconstruction in patients with alcohol-induced mental disorder.

9 Ann Surg Oncol 2008; 15:371-7. TCOG 16 (interim obturator) (radiation prosthesis) (definitive prosthesis) 1. 7-21 (1) 17 (2) (3) (4) (osteoradionecrosis) (1) (2) pH TCOG 18 (3)

10 (4) 60 Gy 2. 19 (1) (maxilla) (hard palate) / (soft palate) (2) (3) (1) / / (immediate surgical obturator, ISO) ISO ISO ISO (definitive obturator) (dental implant) TCOG 20 (2) (microvascular free flap)