Transcription of 報告書 先進医療Aとして実施した粒子線治療（陽子線治療， …
1 A .. A 2019 . 4 2016 2018 . A . A 2016 5 .. 1 1 2.. 2 .. EDC A .. 1. 3 1 2018 7 1 2019 6 30 . 1 28 . 1142 . 20 5. 6.. 6. 2. 0. 0. 0. 0. 0. 1. 79 79. 252 150. 92. 10. 116 99. 17. 418 255. 35. 25. 103. 23 16. 7. 0. 0 0. 234 53. 64. 117. 0 2. 2 16 . 687 . 120 12. 108. 51 9. 24. 18. 386 205. 27. ( ) 4. 150. 1 1. 30 24. 1. 5. 99 29. 28. 42. 0 3 .. 20 0 20 79 0 79 252 120 372 116 51 167 418 386 804 23 1 24 0 30 30 234 99 333 1142 687 1829 . 3. 7:3 . 4 . 1850 .. 1848 0 2 1142.. 1140 0 2 708.. 708 0 0 0%. 2016 17 2017 3 2018.
2 2 2018 .. ( ) . 5 . (%) . 1698 1017 681. (8 ) 11 9 2. 50% 8 7 1. 50% 34 31 3. 23 23 0. 0 0 0. 1 1 0. 54 54 0. 1829 1142 687. 1929 1 1 .. 16 12 . 2 . 4. 6 .. Grade3 Grade3 Grade4 grade5 . 35 33 2 0. 29 27 2 0. 6 6 0 0.. Grade3 Grade3 Grade4 grade5 . 8 8 0 0. 7 7 0 0. 1 1 0 0. Grade3 . 3 .. 7 .. A . B A . A .. 5. 2 .. 19 .. 18 .. 18 11 .. 2 .. 5 2 .. EDC EDC .. 6. 4. 1 2 . 2016 5 2017 6 A .. -1 .. 66 Gy(RBE) /10 . 76 Gy(RBE) / 20 22 . 74 76 Gy(RBE) /37-38 .. Grade 3 8 .. 7. -2 .. (RBE / 4 . (RBE / 12 . (RBE / 12-20.)))
3 1 Grade3 .. 20 . 2 .. 2017 . 8. -1 .. 1) 50-56Gy RBE /25-28 . 2) RBE / 33 . 3) RBE /20-25 . -2 .. Gy(RBE) / 12 .. 2016 .. gemcitabine TS-1 2 . 2 . Blackstock AW 2003 43 5. Okusaka T 2004 42 23. Shibuya K 2011 22 14. Cardenes HR 2011 28 11. Shinchi H 2012 50 27 9. Ikeda M 2013 61 26. -1 .. 1) cT1-T2aN0 66-70Gy RBE) / 10 . cT2b-T3N0 66-70Gy RBE) /10 . 80Gy RBE) / 20 . cT1a-T3N0 80Gy(RBE) / 25 . (RBE) / 22 .. 10. -2 .. 1 1 4 . cT1-T2aN0 (RBE)/4 . (RBE)/1 . (RBE)/12-16 .. cT2b-T3N0 (RBE)/12-16 .. 1 1 4 , (RBE)/12.
4 Grade3 .. 2018 .. Nagata Y. (2005) 3 A:83% B 72 . Nagata Y. (2015) JCOG0403 3 .. Shioyama Y. (2016 3 81%. Ohnishi K. (2019) 3 11.. -3 .. TanyN1-3M0 T4N0M0( .. 60-66Gy RBE) /30-33 . 70-74Gy RBE /35-37 .. 60-70Gy RBE) / 30-35 .. X 2018 . Curren WJ Jr 2011 CDDP+VBL MST . Liang J 2017 PE CDDP ETP MST CP CBDCA+PTX MST . 2018 . Nguyen QN. 2015 MST 30 . Hayashi T. 2017 2 62%. 12.. -1-1 3 .. 49 49 .. ( .. 64Gy RBE) / 8 . (RBE) / 22 .. -1-2 3 .. 29 29 . 17 .. 60Gy (RBE) / 4 50Gy (RBE) / 1 . (RBE) / 12-16.
5 13.. -2-1 3 .. 87 87 .. 64Gy(RBE) / 8 . (RBE) / 22 .. -2-2 3 .. 34 34 . 9 .. (RBE) / 4 (RBE) / 1 . 60-68Gy(RBE) / 4-8fr . 60-68Gy(RBE) / 12-16fr .. 14. MST: . -3-1 .. 150 150 .. 64Gy(RBE) / 8 . (RBE) / 22 . 50-70Gy(RBE) / 25-35 . -3-2 .. 59 59 . 12 .. (RBE) / 12 . 2 (RBE) / 16 .. 15. -4-1 -4-2 . Grade3 . 5.. 2018 7 1 2019 6 30 1 A . 1142 687 1829 .. 2016 5 A . 2 . A .. 16.
