A Guideline for the Clinical Management of

1 A Guideline for the Clinical Management of 1. 2 THIS IS A BLANK PAGE. About the British Columbia Centre on Substance Use & the Canadian Research Initiative in Substance Misuse The BC Centre on Substance Use (BCCSU) is a new provincially networked resource with a mandate to develop, implement and evaluate evidence-based approaches to substance use and addiction. The BCCSU's focus is on three strategic areas including research and evaluation, education and training, and Clinical care guidance. With the support of the province of British Columbia, the BCCSU aims to help establish world leading educational, research and public health, and Clinical practices across the spectrum of substance use. Although physically located in Vancouver, the BCCSU is a provincially networked resource for researchers, educators and care providers as well as people who use substances, family advocates, support groups and the recovery community.

2 The CIHR Canadian Research Initiative on Substance Misuse (CRISM) is a national research consortium uniquely focused on translational and implementation research targeting substance use and related harms, comprising four regional Research Nodes: British Columbia, the Prairie Provinces, Ontario, and Qu bec/Maritimes. The BC CRISM Node is an expert network with over 50 members spanning the province, including knowledge users, service providers, community leaders, and research scientists, all firmly committed to translating the best scientific evidence into practice and policy change, promoting evidence-based approaches to addiction, and training the next generation of leaders through our comprehensive education programs. British Columbia Centre on Substance Use and Ministry of Health. A Guideline for the Clinical Management of opioid Use Disorder. Published June 5, 2017. Available at: 3.

3 AUTHORS AND CONTRIBUTORS. Provincial opioid Use Disorder Treatment Guideline Committee First Nations Health Authority Evan Adams, MD, MPH; Chief Medical Officer, First Nations Health Authority; Adjunct Professor, Faculty of Health Sciences, Simon Fraser University Charl Badenhorst, MD; Medical Officer, First Nations Health Authority; Clinical Faculty, University of British Columbia Nataliya Skuridina; MD, MHSc, FRCPC; Senior Medical Officer, First Nations Health Authority Fraser Health Authority Nader Sharifi, MD, CCFP, Dip. ABAM; Regional Division Head, Addiction Medicine and Addiction Medicine Consul- tant Physician, Fraser Health; Family Physician, Forensic Psychiatric Hospital; Correctional Physician, Correctional Services Canada Nick Mathew, MD, MSc, ABPN, FRCPC, Dip. ABAM; Addiction Division Lead, Surrey Memorial Hospital; Clinical Assistant Professor, University of British Columbia Sharon Vipler, MD, CCFP, Dip.

4 ABAM; Physician, St Paul's Hospital Addiction Medicine Consult Team; Addiction Medicine Physician, Fraser Health Substance Use Services Interior Health Authority Leslie Lappalainen MD, CCFP, Dip. ABAM; Medical Lead for Addiction Medicine, Mental Health and Substance Use Services, Interior Health; Primary Care Physician, Martin Street Outreach Centre (Penticton); Clinical Instructor, University of British Columbia Heather McDonald, MD, CCFP; Lead Physician, Mental Health and Substance Use, Central Okanagan Division of Family Practice Kim Orwaard-Wong, NP(F); Nurse Practitioner, Vernon Primary Care Center, Interior Health Tara Mochizuki, MSW; Manager, Kamloops Mental Health and Substance Use Services, Interior Health Northern Health Authority Gerrard Prigmore, MB, BCh, MRCGP, DFSRH, CCFP, FASAM, Dip. ABAM; Medical Lead, Addiction and Harm Reduction, Northern Health Heather L. Smith, MD, CCFP; Physician, Northern Health; Physician, Central Interior Native Health Society Stephan Ferreira, MD, FASAM, FCFP; Physician, Northern Health Vancouver Island Health Authority Ramm Hering, MD, MSc, CCFP, Dip.

5 PH, Dip. ABAM, FASAM, CCSAM; Addiction Medicine Physician, Mental Health and Substance Use, Island Health; Lead Physician, Rapid Access Addiction Medicine Clinic, Island Health; National Board Member, Canadian Society of Addiction Medicine Bill Bullock, MD, CCFP; Physician, Withdrawal Management Services, Island Health Vancouver Coastal Health Authority and Providence Health Care Keith Ahamad (Committee Co-Chair), MD, CCFP, Dip. ABAM, CISAM; Division Lead Addiction, Department of Family and Community Medicine, Providence Health Care; Physician Lead, St. Paul's Hospital Addiction Medicine 4. Consult Service; Director, Addiction Medicine Enhanced Skills Training Program and Clinical Assistant Professor, University of British Columbia Cassandra Djurfors, MD, CCFP, FCFP; Medical Coordinator, Raven Song Primary Care; Clinical Assistant Professor, University of British Columbia Nadia Fairbairn, MD, FRCPC; Addiction Medicine Physician, St Paul's Hospital; Clinician Scientist, BC Centre for Excellence in HIV/AIDS; Assistant Professor, University of British Columbia Ronald Joe, MD; Associate Medical Director, Vancouver Community Substance Use Services, Vancouver Coastal Health Venu Karapareddy, MBBS, MSc, MRCP sych, FRCPC, MBA; Addiction Psychiatrist, Vancouver Coastal Health; Clinical Assistant Professor, University of British Columbia Jacey Larochelle, RN; Clinical Coordinator, Downtown Eastside (DTES) Connections, Vancouver Coastal Health Mary Marlow, RPN.

6 Manager, Vancouver Community Mental Health & Substance Use Services, Vancouver Coastal Health Mark McLean, MD, MSc, FRCPC, CISAM, Dip. ABAM; Medical Lead, St Paul's Hospital Rapid Access Addiction Clinic;. Physician, St Paul's Hospital Addiction Medicine Consult Team; Medical Coordinator, Vancouver Detox; Clinical Instructor, University of British Columbia Daniel Par , MD, CCFP, Dip. ABAM, CCSAM; Physician, Vancouver Coastal Health Inner City Primary Care & Assertive Community Treatment (ACT) Team; Medical Coordinator, Downtown Community Health Centre (DCHC); Medical Coordinator, Downtown Eastside (DTES) Connections, Vancouver Coastal Health; Clinical Instructor, University of British Columbia Christy Sutherland, MD, CCFP, Dip. ABAM; Medical Director, PHS Community Services Society; Clinical Assistant Professor, University of British Columbia Evan Wood (Committee Chair), MD, PhD, ABIM, FRCPC, Dip.

7 ABAM, FASAM; Canada Research Chair in Inner City Medicine; Nominated Principal Applicant, BC Node of the Canadian Research Initiative in Substance Misuse, Interim Director, British Columbia Centre on Substance Use; Professor of Medicine, University of British Columbia British Columbia Ministry of Health and Other Affiliations Kenneth Tupper, PhD; Director, Problematic Substance Use Prevention, Ministry of Health Diane A. Rothon MD, CM, MPH, CFPC; Medical Director, BC Corrections; Medical Director, Youth Custody Services; Faculty, College of Physicians and Surgeons of BC; Associate, Canadian Institute for Substance Use Research. * NOTE: Committee members participated in Guideline development activities in their individual capacity and not as institutional representatives. 5. External Reviewers Expert Review Panel*. Julie Bruneau, MD, MSc; Professor, Family Medicine and Emergency Department, Universit de Montr al; Head, Department of General Medicine, Centre Hospitalier de l'Universit de Montr al (CHUM).

8 Philip O. Coffin, MD, MIA, FACP; Assistant Clinical Professor, Division of HIV, ID, and Global Medicine, University of California San Francisco (UCSF). David A. Fiellin, MD; Professor of Medicine and Public Health, Yale University School of Medicine Didier Jutras-Aswad, MD, MS; Director, Addiction Psychiatry Unit, and Researcher, Centre Hospitalier de l'Universit . de Montr al; Associate Clinical Professor, Universit de Montr al P. Todd Korthius, MD, MPH; Associate Professor of Medicine and Public Health (joint), Oregon Health and Science University Ronald Lim, MD, CCFP, Dip. ABAM, FASAM, FISAM, CCSAM; Clinical Assistant Professor, Department of Family Practice and Psychiatry, Cumming School of Medicine, University of Calgary Scott MacDonald, MD; Lead Physician, Providence Crosstown Clinic Annabel Mead, MBBS, Dip. ABAM, FAChAM; Director, St Paul's Goldcorp Addiction Medicine Fellowship; Consultant Physician, Complex Pain and Addiction Service, Vancouver General Hospital; Physician, St Paul's Hospital Addiction Medicine Consult Service; Clinical Assistant Professor, University of British Columbia Launette Rieb, MD, MSc, CCFP, FCFP, Dip.

9 ABAM, CCSAM; Medical Consultant, St Paul's Hospital; Physician, Orchard Recovery Centre; Physician, OrionHealth (Vancouver Pain Clinic); Clinical Associate Professor, University of British Columbia Meaghan Thumath, RN, BSN, MScPH; Senior Practice Leader, BC Centre for Disease Control, Provincial Health Services Authority; Trudeau Scholar, Department of Social Policy and Intervention, University of Oxford; Addiction Nursing Fellow, St Paul's Goldcorp Addiction Medicine Fellowship * NOTE: External reviewers participated in Guideline development activities in their individual capacity and not as institutional representatives. Health System Reviewers and Partners 6. Acknowledgements The Guideline committee gratefully acknowledges the College of Pharmacists of British Columbia for their contributions to this work. The committee also wishes to acknowledge Mona Kwong, BSc(Pharm), PharmD, MSc, who provided an independent pharmacist review of Guideline contents and appendices.

10 The committee also wishes to thank the following individuals for their contributions to Guideline development and completion: Pauline Voon and Emily Wagner for primary research and writing assistance; Maryam Babaei, Cameron Collins, Lindsay Farrell, Cheyenne Johnson, Jessica Jun, Diane P pin, Carmen Rock, Josey Ross, Lianlian Ti, and Peter Vann for editorial and administrative support; and James Nakagawa for document layout and design. This work was undertaken, in part, thanks to funding from the Province of British Columbia. Additional funding support was provided by the Canadian Institutes of Health Research through the Canadian Research Initiative in Substance Misuse (SMN 139148) and an Embedded Clinician Researcher Salary Award . Western Canada (TI2-147863), which supports Dr. Keith Ahamad (Committee Co-Chair); and the Canada Research Chairs program through a Tier 1 Canada Research Chair in Inner City Medicine, which supports Dr.