A Real-Time QRS Detection Algorithm

1 IEEETRANSACTIONSONBIOMEDICALENGINEERING, , , ,SENIORMEMBER, ,amplitude, , , [1]-[ , , ,notonlybecauseofthephysio-logicalvariab ilityoftheQRScomplexes, ,artifactsduetoelectrodemotion,power-lin einterference,baselinewander, ,digitalfiltersreducetheinfluenceofthese noisesources, , :lineardigitalfiltering,nonlineartransfo rmation,anddecisionrulealgorithms[4]. ,ManuscriptreceivedJuly27,1984;revisedOc tober24, ,ShanghaiSecondMedicalCollege,Shanghai,P eople' ,UniversityofWisconsin,Madison, , [5]. ,byitsverynature, , , ,wemustex-tractotherparametersfromthesig nalsuchasamplitude,width,andQRSenergy[6] ,[7]. :MIT/BIH[8]andAHA(AmericanHeartAssociati on)[9].Theperformanceofanalgorithmonadat a-baseisnottheultimateanswerastoitsutili tyinaclinicalen-vironment, (Zilog)oranNSC800(NationalSemiconductor) , , ,inordertoattenuatenoise, (b) [ (c)],followedbysquaring[ (d)],andthenmovingwindowintegra-tion[ (e)]. $ 1985 IEEE230 Authorized licensed use limited to: Oxford University Libraries.]

2 Downloaded on November 20, 2009 at 07:45 from IEEE Xplore. Restrictions apply. PANANDTOMPKINS:REAL-TIMEQRSDETECTIONALGO RITHM(a)(b)(c)(d)(e)(f)(g) (a)Originalsignal.(b)Outputofbandpassfil ter.(c)Outputofdifferentiator.(d)Outputo fsquaringprocess.(e)Resultsofmoving-wind owintegration.(f)OriginalECGsignaldelaye dbythetotalprocessingtime.(g) (f) (a) (g) :learningphase1,learningphase2, , , (a)(b)(c)(d)(e) (a)Originalsignal.(b)Out-putofbandpassfi lter.(c)Resultsofmoving-windowintegratio n.(d)OriginalECGsignaldelayedbythetotalp rocessingtine.(e) , ,themaximalpeakdetectedinthattimeinterva lthatliesbetweenthesetwothresholdsiscon- sideredtobeapossibleQRScomplex, ,weavoidrequiringalongmemorybufferforsto ringthepasthistoryoftheECG, , , , , licensed use limited to: Oxford University Libraries. Downloaded on November 20, 2009 at 07:45 from IEEE Xplore. Restrictions apply. IEEETRANSACTIONSONBIOMEDICALENGINEERING, , ,MARCH1985occursfollowingtheendoftherefr actoryperiodbutwithin360msofthepreviousc omplex, , ,aQRSdetectionalgorithmmustadapteachofit sparameterswithtimesoastobeabletooperate properlyforECG' , (lower)thresholds, , , , ' (ADC)samplestheECGatarateof200 , ,60 Hzinterference,baselinewander, [10],( ,real-timere-cursivefilterinwhichpolesar elocatedtocancelzerosontheunitcircleofth ezplane[12].)

3 , , ,wecascadedthelow-passandhigh-passfilter sdescribedbelowtoachievea3dBpassbandfrom about5-12Hz, (Hz).L;(r) ) (1-62H(Z)=(Iz1) (3oT)HwT=sin2(wTI2)(3(1)(2) (nT)=2y(nT-T)-y(nT-2T)+x(nT)-2x(nT-6T)+x (nT-12T)(3) ( ,thesamplesintheoriginalsignal).Thetrans ferfunctionforsuchahigh-passfilterisH(z) =(1+z1))Theamplituderesponseis|H(wT)I=[2 56+sin2(16cT)]1/2cos(wT/2)Thedifferencee quationisy(nT)=32x(nT-16T)-[y(nT-T)+x(nT )-x(nT-32T)].(4)(5)(6)Thelowcutofffreque ncyofthisfilterisabout5Hz,thegainis32, , licensed use limited to: Oxford University Libraries. Downloaded on November 20, 2009 at 07:45 from IEEE Xplore. Restrictions apply. PANANDTOMPKINS:REAL-TIMEQRSDETECTIONALGO RITHM thetransferfunctionH(z)(l/8T)(-z-2-2z-+2 z'+Z2)Theamplituderesponseis|H(wT)j=(1/4 T)[sin(2coT)+2sin(cwT)].Thedifferenceequ ationis[7]y(nT)=(1/8T)[-x(nT-2T)-2x(nT-T )Frequency(Hz)(7)LIaU-~L(8)1:J,,L+2x(nT+ T)+x(nT+2T)].(9) ( ,itapproximatesanidealderivativeoverthis range).

4 , (nT)=[x(nT)] ( ,predominantlytheECGfrequencies). (nT)=(1/N)[x(nT-(N-1)T)+x(nT-(N-2)T)(W-Q S) (a)ECGsignal.(b) :widthoftheintegratorwindow.(11) , , istoonarrow, ,thewindowis30sampleswide(150ms). + (ifPEAKI isthesignalpeak)NPKI= + (ifPEAKI isthenoisepeak)THRESHOLDIl=NPKI+ (SPKI-NPKI)THRESHOLDI2= :PEAKI istheoverallpeak,SPKI istherunningestimateofthesignalpeak,NPKI istherunningestimateofthenoisepeak,THRES HOLDI listhefirstthresholdapplied,andTHRESHOLD 12isthesecondthresholdapplied.(12)(13)(1 4)(15) (10)233+-**+x(nT)]Authorized licensed use limited to: Oxford University Libraries. Downloaded on November 20, 2009 at 07:45 from IEEE Xplore. Restrictions apply. IEEETRANSACTIONSONBIOMEDICALENGINEERING, , ,MARCH1985thatisnotrelatedtotheQRS( ,theTwave). , , , ,SPKI= + (16)Thesetofthresholdsappliedtothefilter edECGisdeterminedfromSPKF= + (ifPEAKF isthesignalpeak)NPKF= + (ifPEAKF isthenoisepeak)THRESHOLDF1=NPKF+ (SPKF-NPKF)THRESHOLDF2= :PEAKF istheoverallpeak,SPKF istherunningestimateofthesignalpeak,NPKF istherunningestimateofthenoisepeak,THRES HOLDF listhefirstthresholdapplied,andTHRESHOLD F2isthesecondthresholdapplied.

5 (17)(18)(19)(20)WhentheQRScomplexisfound usingthesecondthreshold,SPKF= + (21)Forirregularheartrates,thefirstthres holdofeachsetisre- (22) (23)TobeidentifiedasaQRScomplex, (RRIn-I7+RRIn-6+-+RRn)(24) (RR'_7+RR'?6+**-+RR')(25)whereRR' (26)(27)(28)IfaQRScomplexisnotfounddurin gtheintervalspecifiedbytheRRMISSEDLIMIT, ,weinterprettheheartratetoberegularforth eseeightheartbeatsand(29)RRAVERAGE2> (itmustbegreaterthanthe200mslatency), ,itisidentifiedtobeaTwave;other-wise, [8]. , ,twoZ80-basedlaboratorymicrocomputersyst ems,adcamplifier, , , , licensed use limited to: Oxford University Libraries. Downloaded on November 20, 2009 at 07:45 from IEEE Xplore. Restrictions apply. : : ( (No.)Beats)(Beats)(Beats)(Beats)(%) +1V, (theinputvoltagerangeis ).The24 ( )and277falsenegativebeats( ) ,ingeneral,bystretchesofnoise,baselinesh ifts, , , ,ampli-tude, , , ,QRSmorphologies, , [1] , , ,"Design,im-plementation,andevaluationof amicrocomputer-basedportablearrhythmiamo nitor," , , ,1984.

6 [ , , , , , ,Jr.,"Real-timeambulatoryarrhyth-miaanal ysiswithamicrocomputer," , ,1979.[3] , , , , ,"OnlinerecordingandanalysisoftheECGinam bula-torypatients," , ,1981.[4] ,"SoftwareQRSdetectioninambulatorymonito ring-Areview," , , ,1984.[5] ,"Automatedhigh-speedanalysisofHoltertap eswithmicrocomputers," , , , [ ,"AQRS delineationalgorithmwithlowsensitivityto noiseandmorphologychanges," , ,1981.[ ,"Arobust-digitalQRS-detectionalgo-rithm forarrhythmiamonitoring," , , , licensed use limited to: Oxford University Libraries. Downloaded on November 20, 2009 at 07:45 from IEEE Xplore. Restrictions apply. IEEETRANSACTIONSONBIOMEDICALENGINEERING, , ,MARCH1985[8]"MIT/BIHarrhythmiadatabase- Tapedirectoryandformatspec-ification,"Do cumentBMECTR00, ,Cam-bridge, ,Beth-IsraelHospital,330 BrooklineAvenue,Boston,MA02215.[9]"AHAda tabase."DatabaseisavailablefromEmergency CareRe-searchInstitute,5200 ButlerPike,PlymouthMeeting,PA19462.]]]

7 [10] , , , ,"AdigitalQRSdetectorbasedontheprinciple ofcontourlim-iting," , , ,1976.[11] , , ,"OptimalQRSdetector," , , ,1983.[12] ,"Onlinedigitalfilterforbiologicalsignal s:Somefastdesignsforasmallcomputer," , , , ,Shanghai,People' , ,flowcytometryforsinglecellanalysisandso rting,artificialarmcontrolusingelectromy o-graphicsignals,bodysurfacemappinginele ctro-cardiography, ,Cleveland,OH,andthesecondyearwasattheUn iversityofWisconsin,Madison, (S'61-M'66-SM'77) >neermgfromtheUniversityofMaine,Orono,|l mWin1963and1965,respectively, *; 0itheUniversityofPennsylvania,Philadelph ia, ,Inc.,Nashua,NH, ,Madison,wherehisteachingspecialtyisonth etopicofcomputersinmedicine, , ,ofthetextbookDesignofMicrocomputer-Base dMedicalInstrumentation(EnglewoodCliffs, NJ:Prentice-Hall,1981)andco-editor, , , ,ofthetextbookElectronicDevicesforRe-hab ilitation(NewYork:Wiley,1984). (currentlyRegionIVAdministrativeCommitte eRep-resentativeandVicePresidentforTechn icalActivities),theIEEECom-puterSociety, theAssociationfortheAdvancementofMedical Instru-mentation, licensed use limited to: Oxford University Libraries.

8 Downloaded on November 20, 2009 at 07:45 from IEEE Xplore. Restrictions apply.