A YEAR IN REVIEW - Roche

1 A YEAR IN REVIEW . 2020. Roche has faced and weathered many challenges in its nearly 125 years. The solidarity and community we experience now in the fight against COVID-19. will significantly increase our collaboration, and there is no doubt that we will come out of this even stronger.. Severin Schwan, CEO Roche Group See video about Roche in 2020. #Stronger Contents 4 A reliable partner 36 Management perspectives 56 Reporting and strategy 64 . Supporting patients 110 Business REVIEW 118 Corporate Governance 138 Remuneration Report Doing now what patients need next rTogether We believe it is urgent to deliver medical solutions right now.

2 Even as we develop innovations for the future. We are passionate about transforming patients' lives. We are courageous in both decision and action. And we believe that good business means a better world. That is why we come to work each day. We commit ourselves to scientific rigour, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow. We are proud of who we are, what we do, and how we do it. We are many, working as one across functions, across companies, and across the world.

3 We are Roche . A RELIABLE PARTNER. DURING THE CORONA. PANDEMIC. A reliable partner | Roche 5. The reports began to appear, somewhat quietly, in early 2020. But very soon, the alarm began to ring loudly. A virus called SARS-CoV-2 was suddenly dominating the headlines and threatening lives around the world. Roche quickly realised the company had a new mission and a substantial list of vital undertakings. That list included: Developing new diagnostic tools Determining if any existing medicines could combat the infection or ease its symptoms Developing entirely new medicines to treat the virus Joining forces with governments, other business partners and organisations to accelerate progress Securing employee safety while maintaining business continuity to ensure supplies of tests and medicines reached patients in need 6.

4 Nikki is a student at the University of California, Berkeley. After recovering from COVID-19 she is enjoying life again and spending time on her favourite outdoor activities. See more about Nikki's story A reliable partner | Roche 7. It doesn't get any closer to home than this.. Nearly three years ago, Roche employee Michaela received a positive result. Nikki consulted with her Hart's daughter Nikki was diagnosed with a doctors using telemedicine, and travelling healthcare significant illness. But in March 2020, after Nikki's workers came to check her vitals and administer latest hospital visit for treatment, something seemed treatments (including intravenous fluids) through off in a new and very different way.

5 Her partially opened apartment door. Nikki's main concern, Michaela says, was to not infect others. It was Friday the 13th, explains Michaela, Vice President of Quality Systems and Compliance at Taking charge of her own healthcare gave her a Roche Diagnostics in Pleasanton, California. Nikki sense of control, Michaela says. Being involved started feeling sick. She had just been discharged and being her own medical sleuth gave her a way of from the hospital yet again, so it could have been a owning her diagnosis, which is really important for result of her ongoing treatments.

6 But at this point, we patients. With an underlying illness and repeated had to face a new possibility: Could it be COVID-19? episodes of severe dehydration, Nikki's recovery has been a long journey. But she is handling it well. What When Nikki became too sick to continue her really struck Michaela was her daughter's strength, education at the University of California, Berkeley, and her trust in being part of the Roche family both the family moved her home. But, in hopes that as a patient, and as the daughter of an employee.

7 Nikki would soon return to school, they kept Nikki's Her mindset is so very positive and strong, . off-campus apartment. Their goal was to keep Michaela says. everything as normal as possible, and hope for the best. Throughout her career, Michaela has remained focused on being a champion for quality and on But she started feeling really sick, and not in the considering the voice and perspective of the usual ways, Michaela explains. As hard as it was, customer and our patients in her daily workplace I said to her, because this could be COVID-19, decisions.

8 But in this moment, Michaela said, you'd better self-isolate in your apartment. If I get I realised that this time I was the customer, and sick, I can't take care of you.' so was my daughter. It does not get any closer to home than this.. Nikki returned to her apartment, and soon became even sicker, with a high fever. Her doctor recommended that she be tested for COVID-19. The test came back negative. But Nikki was unconvinced. Being involved and being her own She said to her mother, I know it is COVID-19. I have had the flu before.

9 I feel different, and this is a medical sleuth gave her a way of different virus.. owning her diagnosis, which is really Nikki insisted on another COVID-19 test. After a few weeks of waiting and several phone calls, she important for patients.. 8. The future hinges on partnerships.. Looking back on his experience with COVID-19 development goals. But through this experience, is painful for Alain Bindels, Head of Innovation I have realised the importance of solidarity, Facilitation & Digitalisation at Roche . As he explains, sustainability , and building ecosystems to make It was a very tough moment in my life.

10 I really felt change happen.. helpless, and realised how fragile life is. It was really two weeks of not knowing what the outcome An opportunity to harness solidarity around would be. Will I get better? Will I be able to see my the globe family again? The disease transformed Alain, as well as the annual innovation summit he organises. As he He did recover. But Alain says he is not the same observed the creativity and agility spurred by the man he was before the virus. After 15 days on his pandemic, he recognised an opportunity to harness back, a fever as high as degrees Celsius and a solidarity around the globe.