薬剤耐性（AMR - maff.go.jp

1 AMR JVARM 28 JVARM Japanese Veterinary Antimicrobial Resistance Monitoring System 1999 : 1999 30 : JVARM Japanese Veterinary Antimicrobial Resistance Monitoring System 32 JVARM Japanese Veterinary Antimicrobial Resistance Monitoring System 1999 MIC 2000 2003 2004 2007 2008 2015 /

2 2016 2020 AMR) AMR 1,059 t 233 t226 t753t 1,292 t 979 t2001 2014 143 t ( 63%) 0501001502002503003504004502006200720082 00920102011 TCPC +TMP ECDC AMR Surveillance report 2012, Murakiet al., Infection. 2013; 41:415-23. AMR defined dose/1,000 / Rev. sci. tech. Off. int. Epiz., 2014, 33 (3)Y. Hosoiet al. Sales of veterinary antimicrobial agents fortherapeutic use in food-producing animal species in Japan between 2005 and 2010 Quantities of veterinary antimicrobial agents sold for therapeuticuse in Japan in mg/kg biomass of the respective target species, (JVARM)

3 1999 2015 27,240 * *Campylobacter Salmonella Total 19991,0181,024166124194318 2000~20032,2061,386956183211394 2004~20071,9791,920679179482661 2008~20091,2951,273390 371371 2010~20111,5671,432540 325325 2012~20131,4811,486464 369369 2014~20151,3331,400464 343343 TOTAL10,8799,9213,6594862,2952,781 CefazolinCeftiofur : 2000~2009, Cefotaxime: 2010~201142 The resistance rate of cephalosporin in E. coliisolates from healthy broilers HikiM et al. Foodborne Pathog Dis. 2015 Jul;12(7):639-43. 3 ESBL DANMAP 2014 The reductions are, most likely a result of the discontinued use of 3rd generation cephalosporinsin the top of the breeding pyramids in the country producing the has led to a reduction in imported parent flocks harbouringESBL genes.

4 NalidixicacidFluoroquinolone(Enrofloxaci n:2001~2009,Ciprofloxacin:2010~) C. jejuniC. coli ASSuT Salmonella 4,[5],12:i:- NARMS 2012-2013 S. Typhimurium DANMAP 2014 S. Typhimuri 197 4,[5],12:i:- 230 ASSuTASSuTASSuTASSuTCiprofloxacinTMPC iprofloxacinCiprofloxacinCiprofloxacinTM PTMPTMP JVARM JANIS H28 50 JVARM JANIS JVARM JANIS 1999 2000 JANIS JANIS JVARM JVARM JVARM JANIS MIC SIR 2003 2013 6,798 52 JANIS (Ceph)

5 JVARM Ceph 2010 1 Ceph 2012 3 Ceph 2010 3 Ceph BP CTF2/8 g/mL CTX8/64 g/mL)0%20%40%60%200320042005200620072008 20092010201120122013 (ABPC ) JANIS0%5%10%15%20%25%30%2003200420052006 2007200820092010201120122013 (CEZ) 1 JANIS0%5%10%15%20%25%30%2003200420052006 2007200820092010201120122013 CTF / CTX 3 JANIS CTX)CTFCTXCTX2010 CTF BP8 g/mL) CTX(BP 64 g/mL) 0%5%10%15%20%25%30%200320042005200620072 00820092010201120122013 JANIS051015202530352010201120122013 Isolated from broilerCMY-2 CTX-M-1/CTX-M-15 CTX-M-2 CTX-M-25 TEM-135 SHV-12 HikiM et al.

6 Foodborne Pathog Dis. 2015 Jul;12(7) from human 05101520 OtherCTX-M-18 CTX-M-2 CMY-21999 2002 Suzuki S et al. J Antimicrob Chemother. 2009 Jan;63(1):72-9 KojimaA et al. Antimicrob Agents Chemother. 2005 Aug; 49(8): 3533 3537. -Lactamase geneE. coli JANIS 10 3 JVARM 2010 2009 10 0%5%10%15%20%25%30%35%40%200320042005200 62007200820092010201120122013 ERFX / CPFX LVFX JANIS LVFX)LVFXERFXCPFXJVARM 2003-2009 2010 JANIS2003 2006 2007 2013